TITLE

Application of multivariate data-analysis techniques to biomedical diagnostics based on mid-infrared spectroscopy

AUTHOR(S)
Liqun Wang; Mizaikoff, Boris
PUB. DATE
July 2008
SOURCE
Analytical & Bioanalytical Chemistry;Jul2008, Vol. 391 Issue 5, p1641
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The objective of this contribution is to review the application of advanced multivariate data-analysis techniques in the field of mid-infrared (MIR) spectroscopic biomedical diagnosis. MIR spectroscopy is a powerful chemical analysis tool for detecting biomedically relevant constituents such as DNA/RNA, proteins, carbohydrates, lipids, etc., and even diseases or disease progression that may induce changes in the chemical composition or structure of biological systems including cells, tissues, and bio-fluids. However, MIR spectra of multiple constituents are usually characterized by strongly overlapping spectral features reflecting the complexity of biological samples. Consequently, MIR spectra of biological samples are frequently difficult to interpret by simple data-analysis techniques. Hence, with increasing complexity of the sample matrix more sophisticated mathematical and statistical data analysis routines are required for deconvoluting spectroscopic data and for providing useful results from information-rich spectroscopic signals. A large body of work relates to the combination of multivariate data-analysis techniques with MIR spectroscopy, and has been applied by a variety of research groups to biomedically relevant areas such as cancer detection and analysis, artery diseases, biomarkers, and other pathologies. The reported results indeed reveal a promising perspective for more widespread application of multivariate data analysis in assisting MIR spectroscopy as a screening or diagnostic tool in biomedical research and clinical studies. While the authors do not mean to ignore any relevant contributions to biomedical analysis across the entire electromagnetic spectrum, they confine the discussion in this contribution to the mid-infrared spectral range as a potentially very useful, yet underutilized frequency region. Selected representative examples without claiming completeness will demonstrate a range of biomedical diagnostic applications with particular emphasis on the advantageous interaction between multivariate data analysis and MIR spectroscopy.
ACCESSION #
32679633

 

Related Articles

  • SALIVARY PROTEOMIC SIGNATURES OF ORAL SQUAMOUS CELL CARCINOMA. LO RUSSO, L.; PAPALE, M.; PERRONE, D.; RANIERI, E.; RUBINI, C.; GIANNATEMPO, G.; SANTARELLI, A.; COLELLA, G.; LO MUZIO, L. // European Journal of Inflammation (BIOLIFE, s.a.s.);Jan-Apr2012, Vol. 10 Issue 1, p61 

    Delay in diagnosing oral squamous cell carcinoma (OSCC) can be still identified as a major cause of its high morbidity and mortality. To date, the early diagnosis for OSCC is mainly based on clinical oral examination and there is an urgent need for reliable markers; thus, advancements in...

  • Quantification of circulating Epstein-Barr virus DNA in NK/T-cell lymphoma treated with the SMILE protocol: diagnostic and prognostic significance. Kwong, Y-L; Pang, A W K; Leung, A Y H; Chim, C-S; Tse, E // Leukemia (08876924);Apr2014, Vol. 28 Issue 4, p865 

    Circulating Epstein-Barr virus (EBV) DNA is a biomarker of EBV-associated malignancies. Its significance in natural killer/T-cell lymphoma treated with the novel regimen SMILE was investigated. EBV DNA was quantified with a World Health Organization EBV standard in 910 plasma samples collected...

  • Accuracy of plasma sTREM-1 for sepsis diagnosis in systemic inflammatory patients: a systematic review and meta-analysis. Youping Wu; Fei Wang; Xiaohua Fan; Rui Bao; Lulong Bo; Jinbao Li; Xiaoming Deng // Critical Care;2012, Vol. 16 Issue 6, p1 

    Introduction: Early diagnosis of sepsis is vital to the clinical course and outcome of septic patients. Recently, soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) appears to be a potential marker of infection. The objective of this systematic review and meta-analysis was to...

  • Molecular markers of prognosis and novel therapeutic strategies for urothelial cell carcinomas. Thomas, Christopher; Theodorescu, Dan // World Journal of Urology;Oct2006, Vol. 24 Issue 5, p565 

    The article talks about how recent technical advances on urothelial cell carcinomas (UCC) have influenced the development of molecular markers of prognosis and novel therapeutic strategies. Reviews of current data showed the lack of independent prognostic significance in molecular markers and...

  • Combined expression of caveolin-1 and an activated AKT/mTOR pathway predicts reduced disease-free survival in clinically confined renal cell carcinoma. Campbell, L.; Jasani, B.; Edwards, K.; Gumbleton, M.; Griffiths, D. F. R. // British Journal of Cancer;3/4/2008, Vol. 98 Issue 5, p931 

    We previously reported that tumour-associated caveolin-1 is a potential biomarker in renal cell carcinoma (RCC), whose overexpression predicts metastasis following surgical resection for clinically confined disease. Much attention has recently focused on the AKT/mTOR pathway in a number of...

  • Analysis of Cervical Supernatant Samples Luminescence Using 355 nm Laser. Vaitkuviene, A.; Gegzna, V.; Kurtinaitiene, R.; Stanikunas, R.; Rimiene, J.; Vaitkus, J. // AIP Conference Proceedings;5/31/2010, Vol. 1226 Issue 1, p96 

    The biomarker discovery for accurate detection and diagnosis of cervical carcinoma and its malignant precursors represents one of the current challenges in clinical medicine. Laser induced autofluorescence spectra in cervical smear content were fitted to predict the cervical epithelium diagnosis...

  • Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy. Beloueche-Babari, M.; Chung, Y.-L.; Al-Saffar, N. M. S.; Falck-Miniotis, M.; Leach, M. O. // British Journal of Cancer;1/4/2010, Vol. 102 Issue 1, p1 

    Developing rational targeted cancer drugs requires the implementation of pharmacodynamic (PD), preferably non-invasive, biomarkers to aid response assessment and patient follow-up. Magnetic resonance spectroscopy (MRS) allows the non-invasive study of tumour metabolism. We describe the...

  • Computational proteomics: management and analysis of proteomics data.  // Briefings in Bioinformatics;Mar2008, Vol. 9 Issue 2, p97 

    The article discusses various reports published within the issue, including one by Melanie Hilario and Alexander Kalousis which describes the computational methods in biomarker discovery studies and another by Peirangelo Veltri on the characteristics of spectra data.

  • Diagnostic accuracy of biochemical markers of fibrosis in black African patients with chronic hepatitis B. Mahassadi, Alassan Kouamé; Attia, Alain Koffi; Yao Bathaix, Fulgence M.; Agbé, Narcisse Baudouin; Doffou, Stanislas; Ya Kissi, Henriette; Diomandé, Isidore Mouhenou; Cales, Paul; Ndri-Yoman, Thérese // Health (1949-4998);Dec2010, Vol. 2 Issue 12, p1413 

    Contradictory results of the accuracy of biochemical markers to predict the stage of fibrosis in black African patients with chronic hepatitis B (CHB) were previously published. We conducted a prospective cohort study to determine the diagnostic accuracy of aspartate aminotransferase to platelet...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics