TITLE

Arsenic Speciation of Arsine-Exposed Blood Samples by High-Performance Liquid Chromatography—Inductively Coupled Plasma Mass Spectrometry and As-Adduct, A Possible Indicator of AsH3 Exposure

AUTHOR(S)
Higashikawa, Yoshiyasu; Kazui, Yuko; Suzuki, Shinichi; Ohtsuru, Osamu
PUB. DATE
June 2008
SOURCE
Journal of Analytical Toxicology;Jun2008, Vol. 32 Issue 5, p344
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article examines arsine-exposed human blood samples for arsenic speciation using high-performance liquid chromatography with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). Findings show that exposure to arsine can cause hemolysis and production of an unidentified arsenic species (As-adduct). Results also reveal that the As-adduct was not produced by Arsenic and plasma ingredients, but was derived from erythrocytes during the process of hemolysis by arsine. The author concludes that the prescence of As-adduct in the blood samples could be a possible marker for acute arsine intoxication.
ACCESSION #
32669656

 

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