TITLE

Genetic susceptibility to the respiratory effects of air pollution

AUTHOR(S)
Yang, I. A.; Fong, K. M.; Zimmerman, P. V.; Holgate, S. I.; Holloway, J. W.; Holgate, S T
PUB. DATE
June 2008
SOURCE
Thorax;Jun2008, Vol. 63 Issue 6, p555
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
There is large variation between individuals in their response to air pollutants. This review summarises the existing evidence that genetic factors influence the mechanisms of lung injury caused by air pollutants. Genetic association studies have compared the adverse effects of air pollutants between subjects with specific genotypes in biologically relevant genes. In human studies of ozone exposure, polymorphisms in oxidative stress genes (NQO1, GSTM1, GSTP1) modify respiratory symptoms, lung function, biomarkers and risk of asthma. Inflammatory gene polymorphisms (TNF) influence the lung function response to ozone, and the effect of different levels of ozone on the development of asthma. Polymorphisms in oxidative stress genes (GSTM1, GSTP1) alter the response to combined exposure to ragweed pollen and diesel exhaust particles. Importantly, polymorphisms in an oxidative stress gene (GSTM1) have predicted patients with asthma who benefit from antioxidant supplementation in Mexico City, which has chronically high ozone exposure. Genetic linkage studies of families have not been feasible for studying the effects of air pollution in humans, but some progress has been made with pedigrees of specially bred mice, in identifying chromosomal regions linked to effects of ozone or particles. A high priority now, in addition to avoiding exposure in the most susceptible people, is to clearly identify the most effective and safe chemopreventive agents for individuals who are genetically susceptible to the adverse effects of air pollution (eg, antioxidants to be taken during high ozone levels).
ACCESSION #
32637228

 

Related Articles

  • Association of GSTM1 and GSTT1 Polymorphisms with Chronic Obstructive Pulmonary Disease in a Tunisian Population. Lakhdar, Ramzi; Denden, Sabri; Knani, Jalel; Leban, Nadia; Daimi, Houria; Hassine, Mohsen; Lefranc, G�rard; Ben Chibani, Jemni; Haj Khelil, Amel // Biochemical Genetics;Aug2010, Vol. 48 Issue 7/8, p647 

    GSTM1 and GSTT1 polymorphisms have been proposed in relationship with chronic obstructive pulmonary disease (COPD). We investigated the association between these polymorphisms and COPD (as well as its subtypes emphysema and chronic bronchitis) in 234 COPD patients and 182 healthy controls in the...

  • Typhoid fever and genetic polymorphisms at the natural resistance-associated macrophage protein 1. Dunstan, Sarah J.; Dougan, Gordon; Ho, Vo An; Duc, Chau Minh; Lanh, Mai Ngoc; Phuong, Cao Xuan Thanh; Luxemburger, Christine; Wain, John; House, Deborah; Dudbridge, Frank; Peacock, Christopher S.; Blackwell, Jenefer M.; Parry, Christopher; Farrar, Jeremy; Hien, Tran Tinh; Dunstan, S J; Ho, V A; Duc, C M; Lanh, M N; Phuong, C X // Journal of Infectious Diseases;4/1/2001, Vol. 183 Issue 7, p1156 

    Control of Salmonella enterica serovar Typhimurium (S. typhimurium) infection in the mouse model of typhoid fever is critically dependent on the natural resistance-associated macrophage protein 1 (Nramp1). In this study, we examined the role of genetic polymorphisms in the human homologue,...

  • Winter air pollution and respiratory function. Lippmann, M. // Occupational & Environmental Medicine;Feb2003, Vol. 60 Issue 2, p81 

    Editorial. Comments on a study which examined the effects of winter air pollution on the respiratory function of children. Concerns about the effects of air pollution on children; Use of peak expiratory flow rate measurement (PEFR); Association between PEFR and particulate matter in children.

  • A comparative structural bioinformatics analysis of inherited mutations in b-D-Mannosidase across multiple species reveals a genotype-phenotype correlation. Huynh, Thi; Khan, Javed Mohammed; Ranganathan, Shoba // BMC Genomics;2011 Supplement 3, Vol. 12 Issue Suppl 3, p1 

    Background: Lysosomal β-D-mannosidase is a glycosyl hydrolase that breaks down the glycosidic bonds at the non-reducing end of N-linked glycoproteins. Hence, it is a crucial enzyme in polysaccharide degradation pathway. Mutations in the MANBA gene that codes for lysosomal β-mannosidase,...

  • The Genetics of Brain Wiring: From Molecule to Mind. Mitchell, Kevin J. // PLoS Biology;Apr2007, Vol. 5 Issue 4, p0690 

    The article presents an essay on the genetics of brain wiring. It challenges the understanding of how genotype is mapped to phenotype, not just in terms of the average effects of single genes across populations but also in terms of their combined effects in shaping the phenotypes of individuals....

  • Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows. Adam Roberts; Leonard McMillan; Wei Wang; Joel Parker; Ivan Rusyn; David Threadgill // Bioinformatics;Jul2007, Vol. 23 Issue 13, pi401 

    Motivation: Typical high-throughput genotyping techniques produce numerous missing calls that confound subsequent analyses, such as disease association studies. Common remedies for this problem include removing affected markers and/or samples or, otherwise, imputing the missing data. On small...

  • CYP2D6 genotype and phenotype relationship in South Indians. Naveen, A. T.; Prasanna, T.; Farzana, B. L.; Rajan, S.; Adithan, C. // Journal of Postgraduate Medicine;Oct-Dec2006, Vol. 52 Issue 4, p253 

    Background: Genotypes of the drug-metabolizing enzyme CYP2D6 influence plasma levels of 25% of commonly prescribed drugs. This is the first study in India to investigate the genotype-phenotype relationship of CYP2D6. Aim: To study the influence of some CYP2D6 genotypes on the metabolism of its...

  • A Gene-Phenotype Network for the Laboratory Mouse and Its Implications for Systematic Phenotyping. Espinosa, Octavio; Hancock, John M. // PLoS ONE;2011, Vol. 6 Issue 5, p1 

    The laboratory mouse is the pre-eminent model organism for the dissection of human disease pathways. With the advent of a comprehensive panel of gene knockouts, projects to characterise the phenotypes of all knockout lines are being initiated. The range of genotype-phenotype associations can be...

  • Association between asthma-related phenotypes and theCC16 A38Gpolymorphism in an unselected population of young adult Danes. Candelaria, Pierre; Backer, Vibeke; Laing, Ingrid; Porsbjerg, Celeste; Nepper-Christensen, Steen; Klerk, Nick; Goldblatt, Jack; Souëf, Peter // Immunogenetics;Apr2005, Vol. 57 Issue 1/2, p25 

    The gene for Clara cell 16-kDa (CC16) protein is a promising candidate for asthma susceptibility. TheCC16 38Aallele has been associated with decreased CC16 plasma levels and increased incidence of asthma in Australian children. To date these results have not been replicated in adults. Therefore,...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics