TITLE

Cancer of the Esophagus and Stomach

AUTHOR(S)
Khushalani, Nikhil I.
PUB. DATE
June 2008
SOURCE
Mayo Clinic Proceedings;Jun2008, Vol. 83 Issue 6, p712
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Upper gastrointestinal tumors involving the esophagus and the stomach are a serious public health problem worldwide. The West has seen a dramatic increase in the incidence of gastroesophageal cancers in the past 2 decades. Although Barrett esophagus has been well characterized, the exact pathway to developing frank malignancy remains undefined. Current treatments for locoregional disease include surgery, chemotherapy, radiation therapy, or some combination thereof. Clinical trials are currently investigating biologic agents that target signaling pathways in carcinogenesis. Whether this research translates into an improved therapeutic index remains to be seen. This review provides a comprehensive update to physicians and residents who contribute to the care of these patients. Studies in the English language were identified searching PubMed (January 1, 1980, through February 29, 2008) using the terms esophagus, gastric, carcinoma, adenocarcinoma, squamous cell, radiation, chemotherapy, surgery, esophagectomy, and targeted therapy.
ACCESSION #
32617220

 

Related Articles

  • Barrett's oesophagus surveillance.  // Caribbean Health;Apr2001, Vol. 4 Issue 2, p29 

    The article offers information on the Barrett's oesophagus surveillance in Leicester, England. As stated, in the group of 266 not considered suitable for surveillance, only one died from oesophageal cancer but there were 103 deaths from other causes. Moreover, the workers concluded that annual...

  • Targeting angiogenesis in pancreatic cancer: rationale and pitfalls. Whipple, Chery; Korc, Murray // Langenbeck's Archives of Surgery;Nov2008, Vol. 393 Issue 6, p901 

    Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer responsible for over 20% of deaths due to gastrointestinal malignancies. PDAC is usually diagnosed at an advanced stage which, in part, helps to explain its high resistance to chemotherapy and radiotherapy. In addition, the...

  • The association of gastric leptin with oesophageal inflammation and metaplasia. Francois, F.; Roper, J.; Goodman, A.J.; Pei, Z.; Ghumman, M.; Mourad, M.; De Perez, A. Z. Olivares; Perez-Perez, G. I.; Tseng, C-H.; Blaser, M. J. // Gut;Jan2008, Vol. 57 Issue 1, p16 

    Background: Gastro-oesophageal reflux disease complications may reflect imbalances between protective and injurious factors. Through its effects on cell growth, leptin may influence oesophageal mucosal homeostasis. Aims: To determine whether leptin receptors are present in the oesophagus, and...

  • Pseudomyxoma Peritonei Syndrome of Appendiceal Origin: An Overview. Brueggen, Carol; Baird, Gayle; Meisheid, Allison // Clinical Journal of Oncology Nursing;Aug2007, Vol. 11 Issue 4, p525 

    Pseudomyxoma peritonei (PMP) syndrome is an uncommon, slowly progressive condition that usually arises from perforation of an adenoma in the appendix. PMP syndrome is characterized by mucin accumulation in the peritoneal cavity. Mucinous implants are found on all peritoneal surfaces and the...

  • Barrett’s oesophagus: an ideal model to study cancer genetics. di Pietro, Massimiliano; Fitzgerald, Rebecca C. // Human Genetics;Aug2009, Vol. 126 Issue 2, p233 

    Chronic gastro-oesophageal reflux disease can induce a metaplastic change of the distal oesophagus called Barrett’s oesophagus whereby the normal squamous epithelium is substituted by a columnar epithelium. Patients with Barrett’s oesophagus are at increased risk of oesophageal...

  • Genetics of Gastroesophageal Cancer: Paradigms, Paradoxes, and Prognostic Utility. Robertson, Elaine V.; Jankowski, Janusz A. // American Journal of Gastroenterology;Feb2008, Vol. 103 Issue 2, p443 

    Hereditary diffuse gastric cancer and tylosis are autosomal dominant cancer susceptibility syndromes. Accumulating evidence also suggests a genetic contribution to Barrett's esophagus and adenocarcinoma, traditionally considered acquired disorders. In this article we review the current knowledge...

  • Chemotherapy and Radiotherapy.  // Current Medical Literature: Lung Cancer;2010, Vol. 4 Issue 2, p45 

    The article discusses several studies papers on chemotherapy and radiotherapy. It presents information on the use of irinotecan in the treatment of extensive disease (ED) small cell lung cancer (SCLC) as not yet advisable. It cites a study on the risk of esophageal toxicity with the...

  • Surgery and adjuvant chemotherapy. Sasako, Mitsuru // International Journal of Clinical Oncology;Jun2008, Vol. 13 Issue 3, p193 

    It was clearly demonstrated that good local control by either radiotherapy or D2 surgery is essential to cure gastric cancer. D2 surgery can be carried out safely with a large volume of patients and can provide better survival than limited surgery. More extended surgery than D2 cannot provide...

  • CANCERUL GASTRIC OPERABIL - STANDARDE NOI ÅžI VECHI ÃŽN TRATAMENT. CĂINAP, CĂLIN // Clujul Medical;Sep2011, Vol. 84 Issue 3, p323 

    Gastric cancer is currently the only neoplasia with a really decreasing incidence. Despite this fact, every year there are more than 800000 new cases, from which more than 500000 will die due to gastric cancer, which makes gastric cancer one of the most deadly neoplasias. Progress has been made...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics