TITLE

Characteristics of Plasmodium falciparum dhfr Haplotypes That Confer Pyrimethamine Resistance, Kilifi, Kenya, 1987-2006

AUTHOR(S)
Certain, Laura K.; Briceño, Marnie; Kiara, Steven M.; Nzila, Alexis M.; Watkins, William M.; Sibley, Carol Hopkins
PUB. DATE
June 2008
SOURCE
Journal of Infectious Diseases;6/15/2008, Vol. 197 Issue 12, p1743
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Resistance to the antimalarial drug sulfadoxine-pyrimethamine (SP) emerged in Plasmodium falciparum from Asia in the 1960s and subsequently spread to Africa. It is not known whether alleles that confer SP resistance also arose independently in Africa. We defined the coding region and microsatellite haplotypes of dhfr alleles in P. falciparum collected in Kilifi, Kenya, during 1987-2006, which spans the period when SP was first introduced. Isolates that carried a double-mutant or triple-mutant dhfr allele were detected at a low frequency, even during 1987-1988. Each of 2 double mutants carried a unique haplotype, and both were related to wild-type haplotypes from the same population. The number of isolates that carried a triple-mutant dhfr allele increased rapidly after introduction of SP and shared the haplotype of the triple mutant derived form Asia. Weobserved no triple-mutant alleles with haplotypes related to those of the Africa-derived wild-type and double-mutant alleles.
ACCESSION #
32586573

 

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