TITLE

Plasmid DNA-Based Vaccines Protect Mice and Ferrets against Lethal Challenge with A/Vietnam/1203/04 (H5N1) Influenza Virus

AUTHOR(S)
Lalor, Peggy A.; Webby, Richard J.; Morrow, Jane; Rusalov, Denis; Kaslow, David C.; Rolland, Alain; Smith, Larry R.
PUB. DATE
June 2008
SOURCE
Journal of Infectious Diseases;6/15/2008, Vol. 197 Issue 12, p1643
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Plasmid DNA (pDNA) vaccines represent an alternative to conventional inactivated influenza vaccines that are likely to experience supply constraints during a pandemic. Several Vaxfectin-formulated pDNA vaccines were tested in mice and ferrets for efficacy against a lethal challenge with the highly pathogenic A/Vietnam/1203/04 (H5N1) influenza virus strain; the vaccines encoded influenza A virus hemagglutinin (HA), and/or nucleoprotein (NP), and M2 protein. Complete protection from death and disease was achieved in mice and ferrets with 2 doses of a Vaxfectin-formulated vaccine containing H5 HA, NP, and M2 plasmids and in ferrets with only 1 dose. A Vaxfectin-formulated vaccine containing NP and M2p DNA provided significant protection against death in mice and provided some benefit in ferrets (i.e.,17%survival, delayed time to illness and death, and significant reduction in viral load compared with that in negative control animals). These experiments support the clinical testing of pDNA vaccine candidates that may ultimately increase global vaccine supply options during pandemics.
ACCESSION #
32586560

 

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