TITLE

Prognostic factors for progression of liver structural lesions in chronic hepatitis C patients

AUTHOR(S)
Mendez, Liliana S. C.; Nita, Marcelo E.; Ono-Nita, Suzane K.; Mello, Evandro S.; Da Silva, Luiz Caetano; Alves, Venâncio A. F.; Carrilho, Flair J.; Reshetnyak, Vasiliy I.
PUB. DATE
April 2008
SOURCE
World Journal of Gastroenterology;4/28/2008, Vol. 14 Issue 16, p2522
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
AIM: To evaluate the epidemiological, clinical, laboratory and histological variables capable of predicting the progression of hepatic structural disturbances in chronic hepatitis C patients during the time interval between two liver biopsies. METHODS: Clinical charts of 112 chronic hepatitis C patients were retrospectively analyzed, whereas liver biopsies were revised. Immunohistochemical detection of interferon receptor was based on the Envision-Peroxidase System. RESULTS: In the multivariate analysis, the variables in the age at first biopsy, ALT levels, presence of lymphoid aggregates and siderosis were the determinants of the best model for predicting the severity of the disease. The direct progression rate of hepatic structural lesions was significantly higher in untreated patients, intermediate in treated non-responders and lower in treated responders to antiviral therapy (non-treated vs responders, 0.22 ± 0.50 vs -0.15 ± 0.46, P = 0.0053). Immuno-expression of interferon receptor is not a relevant factor. CONCLUSION: The best predictors of the progression of fibrosis are age at the first liver biopsy, extent of ALT elevation, inflammation at liver histology and hepatic siderosis. Antiviral treatment is effective in preventing the progression of liver structural lesions in chronic hepatitis C patients.
ACCESSION #
32582918

 

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