Eating disorders and headache: coincidence or consequence?

Ostuzzi, Roberto; D'Andrea, Giovanni; Francesconi, Federica; Musco, Francesca
May 2008
Neurological Sciences;May2008 Supplement 1, Vol. 29, p83
Academic Journal
The eating disorders (ED) anorexia nervosa (AN) and bulimia nervosa (BN) are important psychiatric and somatic conditions occurring mainly in young women. The aetiology is unknown, but there are social, biological and psychological factors that play a relevant role in the pathogenesis, along with multiple endocrine abnormalities. Hypothalamic monoamines (especially serotonin), neuropeptides (especially neuropeptide Y and cholecystokinin) and leptin are involved in the regulation of the human appetite. ED share with migraine the same metabolic profile and aspect of psychiatric and psychological conditions. In support of this hypothesis in one study, it has been shown that the incidence of migraine is high in these patients; and it has been shown that the incidence in a female group that suffers from migraine was greater than in the normal population. In order to understand the possible relationship between migraine and ED, we have investigated the incidence of primary headache in a group of AN and BN patients. The result of this study shows that the prevalence of migraine in women affected by AN and BN is very high (75%) in comparison to the general population (12.5% headache incidence in normal population). In most patients the onset of migraine attacks began before or at the same time as the symptoms of AN and BN. We suggest that migraine is a predisposing condition for the occurence of AD in young women.


Related Articles

  • Study of tyrosine metabolism in eating disorders. Possible correlation with migraine. D'Andrea, Giovanni; Ostuzzi, Roberto; Bolner, Andrea; Francesconi, Federica; Musco, Francesca; d'Onofrio, Florindo; Colavito, Davide // Neurological Sciences;May2008 Supplement 1, Vol. 29, p88 

    In order to understand the possible role of tyrosine metabolism and in particular that of elusive amines in the pathogenesis of eating disorders (ED), we measured the plasma levels of dopamine, noradrenaline, tyramine (Tyr) and octopamine (Oct) in a large group of anorexic and bulimic patients....

  • zolmitriptan. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p814 

    A definition of the term "zolmitriptan" is presented. It refers to a serotonin agonist used for treating acute attacks of migraine.

  • Biochemistry Migraine- Serotonin.  // Journal of Learning Disabilities;May1974, Vol. 7 Issue 5, p295 

    This article presents information on the role of serotonin precursors in migraine biochemistry. A new theory has been proposed for the interpretation of the headache mechanism, in the form of an evolution of the serotonin pathogenesis. According to the migraine-headache serotonin theory...

  • 5HT1F- and 5HT7-Receptor Agonists for the Treatment of Migraines. Agosti, Reto M. // CNS & Neurological Disorders - Drug Targets;2007, Vol. 6 Issue 4, p235 

    Serotonin was the first neurotransmitter believed to be involved in cephalic pain transfer forward to the cortex, but the precise mechanism was confirmed only after sumatriptan, a 5-HT1B/1D high affinity agonist, was introduced in the acute treatment of migraine. Although very efficient for...

  • Can we Develop Neurally Acting Drugs for the Treatment of Migraine? Goadsby, Peter J. // Nature Reviews Drug Discovery;Sep2005, Vol. 4 Issue 9, p741 

    Serotonin (5-HT)1B/1D receptor agonists, which are also known as triptans, represent the most important advance in migraine therapeutics in the four millennia that the condition has been recognized. The vasoconstrictive activity of triptans produced a small clinical penalty in terms of coronary...

  • A Comprehensive Medicine Approach to Migraines. Thitelbaum, Jacob // Townsend Letter for Doctors & Patients;Jan2005, Issue 258, p40 

    This article presents a comprehensive medicine approach to migraines. There is still marked debate over the cause of migraines. For decades, researchers thought that these occurred because of excessive contraction and expansion of the blood vessels in the brain. Others thought that this blood...

  • Quality of life, eating and mood disorders in menstrual migraine: a case-control study. Nicodemo, Marianna; Vignatelli, Luca; Grimaldi, Daniela; Sancisi, Elisa; Fares, Jean Elia; Zanigni, Stefano; Pierangeli, Giulia; Cortelli, Pietro; Montagna, Pasquale; Cevoli, Sabina // Neurological Sciences;May2008 Supplement 1, Vol. 29, p155 

    The aim of this study was to evaluate the prevalence of mood and eating disorders in patients with menstrual migraine. Quality of life and disability were also assessed. The study confirmed the presence of significant disability and poor quality of life due to migraine even in a selected...

  • A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach. Johnson, Matthew; Griffiths, Lyn // Journal of Human Genetics;Dec2005, Vol. 50 Issue 12, p607 

    Migraine is a common debilitating primary headache disorder with significant mental, physical and social health implications. The brain neurotransmitter 5-hydroxytryptamine (5-HT; serotonin) is involved in nociceptive pathways and has been implicated in the pathophysiology of migraine. With few...

  • Theories about migraine.  // Mayo Clinic on Headache;2005, p19 

    This article discusses two theories about the cause of migraine. The first theory assumes that a genetic defect causes an abnormal release of neurotransmitters in the brain. This leads to a state of hyperexcitability in the brain and an abnormal response to one or more stimulating factors. The...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics