TITLE

Change in bone mineral density as a function of age in women and men and association with the use of antiresorptive agents

AUTHOR(S)
Berger, Claudie; Langsetmo, Lisa; Joseph, Lawrence; Hanley, David a.; Davison, K. Shawn; Josse, Robert; Kreiger, Nancy; Tenenhouse, Alan; Goltzman, David
PUB. DATE
June 2008
SOURCE
CMAJ: Canadian Medical Association Journal;6/17/2008, Vol. 178 Issue 13, p1660
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Measurement of bone mineral density is the most common method of diagnosing and assessing osteoporosis. We sought to estimate the average rate of change in bone mineral density as a function of age among Canadians aged 25-85, stratified by sex and use of antiresorptive agents. Methods: We examined a longitudinal cohort of 9423 participants. We measured the bone mineral density in the lumbar spine, total hip and femoral neck at baseline in 1995-1997, and at 3-year (participants aged 40-60 years only) and 5-year follow-up visits. We used the measurements to compute individual rates of change. Results: Bone loss in all 3 skeletal sites began among women at age 40-44. Bone loss was particularly rapid in the total hip and was greatest among women aged 50-54 who were transitioning from premenopause to postmenopause, with a change from baseline of -6.8% (95% confidence interval [CI] -7.5% to -4.9%) over 5 years. The rate of decline, particularly in the total hip, increased again among women older than 70 years. Bone loss in all 3 skeletal sites began at an earlier age (25-39) among men than among women. The rate of decline of bone density in the total hip was nearly constant among men 35 and older and then increased among men older than 65. Use of antiresorptive agents was associated with attenuated bone loss in both sexes among participants aged 50-79. Interpretation: The period of accelerated loss of bone mineral density in the hip bones occurring among women and men older than 65 may be an important contributor to the increased incidence of hip fracture among patients in that age group. The extent of bone loss that we observed in both sexes indicates that, in the absence of additional risk factors or therapy, repeat testing of bone mineral density to diagnose osteoporosis could be delayed to every 5 years.
ACCESSION #
32537414

 

Related Articles

  • Early effect of nasal salmon calcitonin on the bone marker Crosslaps. Ofluoglu, Demet; Karadag-Saygi, Evrim; Canbulat, Cuneyt; Gunduz, Osman Hakan; KUL-Panza, Evren; Akyuz, Gulseren // Rheumatology International;Feb2006, Vol. 26 Issue 4, p288 

    The aim of this study was to investigate the early effect of nasal salmon calcitonin on a bone-resorption marker, “Crosslaps”, in postmenopausal osteoporotic women. In this randomized, single-blind and placebo-controlled study we included 78 postmenopausal women with osteoporosis,...

  • MALE AGEING AND BONE MINERAL DENSITY IN A SAMPLE OF PORTUGUESE MEN. Lucas, Raquel; Silva, Cláudia; Costa, Lúcia; Araújo, Domingos; Barros, Henrique // Acta Reumatológica Portuguesa;2008, Vol. 33 Issue 3, p306 

    Aim: In this study we aimed to estimate the prevalence of osteoporosis and to identify the factors associated with bone mineral density in Portuguese men and to quantify age-related bone loss. Participants and methods: We designed a cross-sectional evaluation of 739 apparently healthy men (20-82...

  • Correlation of different bone markers with bone density in patients with rheumatic diseases on glucocorticoid therapy. Loddenkemper, Konstanze; Bohl, Nicole; Perka, Carsten; Burmester, Gerd-Rüdiger; Buttgereit, Frank // Rheumatology International;Feb2006, Vol. 26 Issue 4, p331 

    Osteoporosis is a common concomitant disease in patients with rheumatic diseases on glucocorticoid (GC) therapy. Bone status is usually evaluated by determination of bone density in combination with clinical examinations and laboratory tests. However, the strength of individual biochemical bone...

  • Ultrasound of Calcaneus as a screening method for diagnostic of Osteoporois. Alimanovic-Alagic, Rubina // HealthMed;2010 Supplement 2, Vol. 4, p1120 

    No abstract available.

  • Recombinant Full-Length Parathyroid Hormone (1-84): A Viewpoint by David Hosking. Hosking, David // Drugs;2006, Vol. 66 Issue 18, p2382 

    â–´ The fentanyl buccal tablet (FBT) is a new formulation of fentanyl that uses an effervescent drug delivery system to enhance penetration across the buccal mucosa for the treatment of breakthrough pain in opioid-tolerant patients with cancer.â–´ Fentanyl is rapidly absorbed from FBT...

  • Changes in soft tissue composition are the primary predictors of 4-year bone mineral density changes in postmenopausal women. Milliken, L. A.; Cussler, E.; Zeller, R. A.; Choi, J.-E.; Metcalfe, L.; Going, S. B.; Lohman, T. G. // Osteoporosis International;Feb2009, Vol. 20 Issue 2, p347 

    Changes in body weight influence bone mineral density, but the role of body composition is not clear in postmenopausal women. Body weight and soft tissue composition predicted bone changes independent of calcium supplementation and exercise frequency, indicating that soft tissue composition...

  • Bone mineral density of girls with idiopathic scoliosis: a comparative study. Ameri, Ebrahim; Ghandehari, Hasan; Shafipour, Reza // Tehran University Medical Journal;Nov2012, Vol. 70 Issue 8, p500 

    Background: Several studies have suggested higher incidence of osteoporosis in patients with idiopathic scoliosis in comparison with the normal population. The aim of this study was to assess the prevalence of low bone mass among adolescent girls with idiopathic scoliosis. Methods: In this...

  • Bone Mineral Density and Bone Histomorphometry are Statistically Related. Todisco, Marzio; Trisi, Paolo // International Journal of Oral & Maxillofacial Implants;Nov/Dec2005, Vol. 20 Issue 6, p898 

    Purpose: The aim of this study was to evaluate how closely analysis of bone quality performed using the bone mineral density (BMD) values obtained by quantitative computerized tomography (QCT) reflected the histologic bone density. Materials and Methods: Eighteen patients requiring implant...

  • Metacarpal Bone Density in Carpal Tunnel Syndrome Patients Without Thenar Atrophy. Savas, Serpil; Okudan, Berna; KoyuncuoE7;, Hasan Rifat; Çelik, Hakan; Karaaslan, Tamer; Yildiz, Mustafa // Romatizma/Rheumatism;mar2007, Vol. 22 Issue 1, p15 

    Objective: Bone loss due to thenar atrophy was reported in the metacarpal bones in premenopausal patients with carpal tunnel syndrome (CTS). The present study was designed to assess bone density in the metacarpal bones in patients with CTS without thenar atrophy and to correlate the metacarpal...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics