TITLE

Individual Radiosensitivity and its Relevance to Health Physics

AUTHOR(S)
Schnarr, Kara; Dayes, Ian; Sathya, Jinka; Boreham, Douglas
PUB. DATE
October 2007
SOURCE
Dose-Response;2007, Vol. 5 Issue 4, p333
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Radiation protection regulations have been established to reduce exposure of individuals to acceptable safe levels. These limits assume that people have similar responses to ionizing radiation and that there is no variation in individual radiation risk. The purpose of this research was to determine if apoptosis in lymphocytes can be used to assess individual sensitivity to ionizing radiation. Blood samples were taken from 54 males ranging in age from 19-85 years. Apoptosis was measured using modified flow cytometry based Annexin-FITC/7AAD and DiOC6/7AAD assays in different populations of lymphocytes (total mixed lymphocyte population, subset CD4+ or CD8+ lymphocytes) after exposure to in vitro doses of 0, 2, 4 or 8Gy (dose rate 0.1Gy/min). The variation in individual responses to radiation was large. The variation was the largest in the CD4+ lymphocyte sub-population. Radiation-induced apoptosis decreased with age of donor demonstrating that as people age their lymphocytes may become relatively more resistant to radiation. This research shows that individuals have marked differences in their sensitivity to radiation and protection policies may someday need to be tailored for some individuals.
ACCESSION #
32523429

 

Related Articles

  • The Australasian Radiation Protection Society's Position Statement on Risks from Low Levels of Ionizing Radiation. Higson, Donald // Dose-Response;2007, Vol. 5 Issue 4, p299 

    Controversy continues on whether or not ionizing radiation is harmful at low doses, with unresolved scientific uncertainty about effects below a few tens of millisieverts. To settle what regulatory controls should apply in this dose region, an assumption has to be made relating dose to the...

  • B–cell responses: Pass the parcel. Leavy, Olive // Nature Reviews Immunology;Sep2007, Vol. 7 Issue 9, p657 

    The article presents a study that B cells encounter antigenic particle at the subcapsular sinus and can act as antigen-transport cells. B cells are usually found in lymphoid follicles, but large antigen complexes cannot passively diffuse into the follicles. The idea of an antigen-transport cell...

  • TOLL-like receptor ligands stimulate aberrant class switch recombination in early B cell precursors. Efrat Edry; Hilla Azulay-Debby; Doron Melamed // International Immunology;Dec2008, Vol. 20 Issue 12, p1575 

    TOLL-like receptor (TLR) ligands stimulate class switch recombination (CSR) in mature B cells. We showed earlier that developing B cells in the bone marrow (BM) express TLR9 and are responsive to CpG DNA. Since CSR is a critical process for synthesis of effector antibodies, we studied the...

  • Activation-induced endocytosis of the raft-associated transmembrane adaptor protein LAB/NTAL in B lymphocytes: evidence for a role in internalization of the B cell receptor. Cathlin M. Mutch; Ratna Sanyal; Tammy L. Unruh; Lana Grigoriou; Minghua Zhu; Weiguo Zhang; Julie P. Deans // International Immunology;Jan2007, Vol. 19 Issue 1, p19 

    Linker for activation of B cell (LAB)/non-T cell activation linker (NTAL) and phosphoprotein associated with glycophospholipid-enriched membrane microdomain (PAG)/Csk-binding protein (Cbp) are raft-associated transmembrane adaptor proteins with distinct functions in immediate/early phases of...

  • Primary Diffuse Large B-Cell Lymphoma of Bone Displays Preferential Rearrangements of the c-MYC or BCL2 Gene. Marina Bousquet; Anne Gomez-Brouchet; Geisilene de Paiva; Eliane Amstalden; Fernando Soares; Nicole Dastugue; Jose Vassallo; Pierre Brousset // American Journal of Clinical Pathology;May2008, Vol. 129 Issue 5, p723 

    We selected a series of 63 primary diffuse large B-cell lymphomas (DLBCLs) of bone collected in tissue microarrays from centers in France and Brazil. These cases were classified according to the expression of antigens associated with germinal center (GC; n = 42) or non-GC (n = 21) stages of...

  • iNKT Cells Control Mouse Spontaneous Carcinoma Independently of Tumor-Specific Cytotoxic T Cells. Bellone, Matteo; Ceccon, Monica; Grioni, Matteo; Jachetti, Elena; Calcinotto, Arianna; Napolitano, Anna; Freschi, Massimo; Casorati, Giulia; Dellabona, Paolo // PLoS ONE;2010, Vol. 5 Issue 1, p1 

    Background: CD1d-restricted invariant NKT (iNKT) cells are a subset of T lymphocytes endowed with innate effector functions that aid in the establishment of adaptive T and B cell immune responses. iNKT cells have been shown to play a spontaneous protective role against experimental tumors. Yet,...

  • Cephalon Submits Treanda NDA: Orphan Drug For CLL. Osborne, Randall // BioWorld Today;9/24/2007, Vol. 18 Issue 185, p1 

    The article reports that Cephalon Inc. submitted its new drug application for the orphan drug Treanda, which targets chronic B-cell lymphocytic leukemia (CLL) and is being developed for non-Hodgkin's lymphoma as well. Cephalon would make a payment to former shareholders of Salmedix Inc., which...

  • Adjuvant Effect of Killed Propionibacterium acnes on Mouse Peritoneal B-1 Lymphocytes and Their Early Phagocyte Differentiation. Mussalem, Juliana Sekeres; Squaiella-Baptist�o, Carla Cristina; Teixeira, Daniela; Yendo, Tatiana Mina; Thies, Felipe Garutti; Popi, Ana Flavia; Mariano, Mario; Longo-Maug�ri, Ieda // PLoS ONE;Mar2012, Vol. 7 Issue 3, p1 

    B-1 lymphocytes are the predominant cells in mouse peritoneal cavity. They express macrophage and lymphocyte markers and are divided into B-1a, B-1b and B-1c subtypes. The role of B-1 cells is not completely clear, but they are responsible for natural IgM production and seem to play a regulatory...

  • B cell.  // American Heritage Student Science Dictionary;2009, p35 

    A definition of the term "B cell" is presented. The term refers to any of the lymphocytes that develop into plasma cells in the presence of a specific antigen, such as a bacterium or virus. The plasma cells then produce antibodies that attack or neutralize the antigen. B cells mature in the bone...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics