TITLE

A Thermodynamic Switch for Chromosome Colocalization

AUTHOR(S)
Nicodemi, Mario; Panning, Barbara; Prisco, Antonella
PUB. DATE
May 2008
SOURCE
Genetics;May2008, Vol. 179 Issue 1, p717
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A general model for the early recognition and colocalization of homologous DNA sequences is proposed. We show, on thermodynamic grounds, how the distance between two homologous DNA sequences is spontaneously regulated by the concentration and affinity of diffusible mediators binding them, which act as a switch between two phases corresponding to independence or colocalization of pairing regions.
ACCESSION #
32518833

 

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