Menor incidencia de daño grave en órganos diana en pacientes mexicanos con esclerosis sistémica con afección cutánea difusa

Rojas-Serrano, Jorge; Codina-Velásquez, Helga; Medrano-Ramírez, Gabriel; Simón, J. Abraham; Vera-Lastra, Olga; Vázquez-Mellado, Janitzia
January 2008
Reumatologia Clinica;ene/feb2008, Vol. 4 Issue 1, p3
Academic Journal
Objective: To determine the cumulative incidence of severe organ involvement in Mexican patients with systemic sclerosis (SS) and diffuse scleroderma at 3 years from the onset of SS symptoms, and to compare it with the cumulative incidence observed in a cohort of white patients with SS. Patients and method: Patients with SS and diffuse scleroderma were evaluated within the first 2 years from the onset of SS symptoms and were included. An estimation of the cumulative incidence of severe involvement to the skin, kidney, heart, lungs, and gastrointestinal track at 3 years from the onset of SS symptoms was carried out. This cumulative incidence was compared with that of white SS patients with diffuse scleroderma, using the one sample test for a binomial proportion. Results: Sixty-three patients were included. The cummulative incidence of severe involvement to the skin was 3.17% (2/63) (95% CI, 0.04%-11); kidney involvement in 4.17% (3/63) (95% CI, 0.99%-13.29%); heart involvement in 1.6% (1/63) (95% CI, 0.049/0-8.5%); lung involvement in 11.11% (7/63) (95% IC, 4.5%- 21.5%); and gastrointestinal involvement in 4.7% (3/63) (95% IC, 0.99%-13.3%). Mexican patients had a lower incidence of severe skin involvement (P=.0001), kidney involvement (P=.03) and heart involvement (P=.03) compared to white SS patients with diffuse scleroderma. Conclusions: The cumulative incidence of severe organ involvement in SS Mexican patients with diffuse sclerodemla was determined. The incidence of severe skin, kidney and heart involvement is lower than in white SS patients with diffuse scleroderma.


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