C-Reactive Protein in Relation to the Development of Microalbuminuria in Type 1 Diabetes

Marcovecchio, M. Loredana; Giannini, Cosimo; Widmer, Barry; Dalton, R. Neil; Martinotti, Stefano; Chiarelli, Francesco; Dunger, David B.
May 2008
Diabetes Care;May2008, Vol. 31 Issue 5, p974
Academic Journal
OBJECTIVES -- To perform a longitudinal evaluation of high-sensitivity C-reactive protein (hs-CRP) in young people with type 1 diabetes in relation to the development of microalbuminuria (MA). RESEARCH DESIGN AND METHODS -- hs-CRP was measured in 329 blood samples collected from 49 subjects with type 1 diabetes with MA and 49 normoalbuminuric subjects matched for age, sex, and duration of diabetes. RESULTS -- In subjects developing MA, a progressive rise in hs-CRP was detected with levels significantly higher in the years after the onset of MA when compared with levels before MA onset (P = 0.003; age-adjusted P = 0.06). After the onset of MA, hs-CRP levels were significantly higher in subjects with MA when compared with normoalbuminuric subjects (median 1.9 mg/l [range 0.2-9.8] vs. 1.1 mg/l [0.2-6.4]; P = 0.02; adjusted P = 0.036). CONCLUSIONS -- In this population of young subjects with type 1 diabetes, there was a significant increase in hs-CRP levels after the onset of MA, likely reflecting a general state of inflammation.


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