TITLE

Preimplantation genetic diagnosis as a source of human embryonic stem cell lines

AUTHOR(S)
Y., Verlinsky; N., Strelchenko; V., Kukharenko; A., Shkumatov; S., Rechitsky; O., Verlinsky; A., Kuliev
PUB. DATE
April 2008
SOURCE
Reproductive BioMedicine Online (Reproductive Healthcare Limited;Apr2008 Supplement 3, Vol. 16, pS-15
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Preimplantation genetic diagnosis (PGD) is presently the major source for the establishment of human embryonic stem cell (ESC) lines with genetic abnormalities, providing the basis for studying of the primary mechanisms of genetic disorders, and the development of the approaches for their effective therapy. We have presently developed the genetic disease specific human ESC line repository, consisting of a total of 58 genetically abnormal lines. It contains 10 human ESC lines with chromosomal abnormalities, including two translocations, three trisomies, two triploidies and three sex chromosomal aneuploidies, and 48 with different single gene disorders, 13 obtained from the embryos with autosomal recessive mutations, 12 X-linked and 23 autosomal dominant disorders, the latter including human ESC lines with dynamic mutations and those with genetic predisposition to cancer. The resulting collection represents the world's first human ESC bank with genetic disorders, currently available for stem cell research of genetic and acquired disorders (www.stemride. com).
ACCESSION #
32140161

 

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