TITLE

Gold nanoparticles for the development of clinical diagnosis methods

AUTHOR(S)
Baptista, Pedro; Pereira, Eulália; Eaton, Peter; Doria, Gonçalo; Miranda, Adelaide; Gomes, Inês; Quaresma, Pedro; Franco, Ricardo
PUB. DATE
June 2008
SOURCE
Analytical & Bioanalytical Chemistry;Jun2008, Vol. 391 Issue 3, p943
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The impact of advances in nanotechnology is particularly relevant in biodiagnostics, where nanoparticle-based assays have been developed for specific detection of bioanalytes of clinical interest. Gold nanoparticles show easily tuned physical properties, including unique optical properties, robustness, and high surface areas, making them ideal candidates for developing biomarker platforms. Modulation of these physicochemical properties can be easily achieved by adequate synthetic strategies and give gold nanoparticles advantages over conventional detection methods currently used in clinical diagnostics. The surface of gold nanoparticles can be tailored by ligand functionalization to selectively bind biomarkers. Thiol-linking of DNA and chemical functionalization of gold nanoparticles for specific protein/antibody binding are the most common approaches. Simple and inexpensive methods based on these bio-nanoprobes were initially applied for detection of specific DNA sequences and are presently being expanded to clinical diagnosis. [Figure not available: see fulltext.]
ACCESSION #
32021861

 

Related Articles

  • Andor Technology plc.  // Spectroscopy;Dec2009, Vol. 24 Issue 12, p18 

    The article presents a company profile for Andor Technology PLC. The company is recognized as the leading manufacturer of high performance modular spectroscopy detection solutions. Detection solutions offers a combination of sensitivity, speed, and ease-of-use. Also, the company markets products...

  • DETECTION OF CANCER BIOMARKERS WITH NANOTECHNOLOGY. Lei Zhang; Dan Lv; Weijun Su; Yanhua Liu; Yanan Chen; Rong Xiang // American Journal of Biochemistry & Biotechnology;2013, Vol. 9 Issue 1, p71 

    Early detection of cancer biomarkers with high precision is critically important for cancer therapy. A variety of sensors based on different nanostructured materials have attracted intensive research interest due to their potential for highly sensitive and selective detection of cancer...

  • Spectroscopy Challenge 8. Meusinger, Reinhard // Analytical & Bioanalytical Chemistry;Nov2004, Vol. 380 Issue 5/6, p729 

    Presents the eight spectroscopy challenge concerning the identity of biochemical compounds whose biological activity was well-known long before chemists investigated their structure. Nomenclature used for all the forms of the substance; Molecular spectra given in the spectroscopy challenge.

  • Two-pulse echo experiments in the spectral diffusion regime. Berg, Mark A.; Rector, K. D.; Rector, K.D.; Fayer, M. D.; Fayer, M.D. // Journal of Chemical Physics;8/22/2000, Vol. 113 Issue 8 

    The two-pulse echo sequence is examined for the case in which the frequency modulation time Ï„[sub m] of the transition is intermediate between the well known limiting cases of very fast modulation (motional narrowing) and very slow or static modulation (inhomogeneous broadening). Within this...

  • Marker, Culture Advances Give Plentiful Adult Stem Cell Source. Breindl, Anette // BioWorld Today;9/20/2007, Vol. 18 Issue 183, p1 

    The article discusses the results of a study on a marker that can be used to isolate cells that can be coaxed into becoming multipotent stem cells. The cells different from embryonic stem cells in terms of their biochemistry, considering their multipotency. Also, the cells do not produce certain...

  • Computational proteomics: management and analysis of proteomics data.  // Briefings in Bioinformatics;Mar2008, Vol. 9 Issue 2, p97 

    The article discusses various reports published within the issue, including one by Melanie Hilario and Alexander Kalousis which describes the computational methods in biomarker discovery studies and another by Peirangelo Veltri on the characteristics of spectra data.

  • Hierarchical analysis of molecular spectra. Davis, Michael J. // Journal of Chemical Physics;2/15/1993, Vol. 98 Issue 4, p2614 

    A method of characterizing molecular spectra is proposed here. Hierarchical trees are generated from molecular spectra by following the branching of peaks as resolution is changed continuously. The trees are analyzed using several techniques developed in the classification and multivariate...

  • Semiclassical quantization of slightly nonresonant systems: Avoided crossings, dynamical tunneling, and molecular spectra. Farrelly, David; Uzer, T. // Journal of Chemical Physics;7/1/1986, Vol. 85 Issue 1, p308 

    An important problem in the spectroscopy of isolated molecules is the passage of a system through an isolated internal nonlinear resonance as the total energy is changed. The spectral signature of such a passage may involve an avoided crossing together with pre-resonant attraction and/or...

  • Oxford Nanopore Raises £17M for Protein Analysis System. Moran, Nuala // BioWorld International;2/3/2010, Vol. 15 Issue 5, p1 

    The article reports on the success of Oxford Nanopore Technologies Ltd. to raise 17.4 million pounds in new funding, which enables the company to continue with the development of its real-time single molecule identification platform. Because of the funding, the company will be able to apply its...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics