In situ molecular imaging of proteins in tissues using mass spectrometry

Hardesty, William M.; Caprioli, Richard M.
June 2008
Analytical & Bioanalytical Chemistry;Jun2008, Vol. 391 Issue 3, p899
Academic Journal
The article provides information on the analysis of molecular location-specific information for the characterization of protein distributions from thin sections of intact biological tissue using matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS). It presents the application of MALDI IMS to a stage 3 metastatic melanoma invading the lymph node. It suggests that the development of top-down proteomic methods for in situ MALDI IMS will add value to this technology.


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