Reversible Neutrophil Abnormalities Related to Supratherapeutic Valproic Acid Levels

Singh, Nishith K.; Nagendra, Sanjai
May 2008
Mayo Clinic Proceedings;May2008, Vol. 83 Issue 5, p600
Academic Journal
The article focuses on the 58-year-old man who had seizures and was taking valproic acid for six months under a daily dose of 1000 milligrams in the morning and 1500 milligrams at night. It cites that upon routine work-up the patient was found to have an anemia, leukopenia, and thrombocytopenia. It states that the findings revealed myelodysplastic syndrome where peripheral blood smear showed neutrophils with abnormal bilobed nuclei but normal cytoplasmic granularity.


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