TITLE

Reversible Neutrophil Abnormalities Related to Supratherapeutic Valproic Acid Levels

AUTHOR(S)
Singh, Nishith K.; Nagendra, Sanjai
PUB. DATE
May 2008
SOURCE
Mayo Clinic Proceedings;May2008, Vol. 83 Issue 5, p600
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article focuses on the 58-year-old man who had seizures and was taking valproic acid for six months under a daily dose of 1000 milligrams in the morning and 1500 milligrams at night. It cites that upon routine work-up the patient was found to have an anemia, leukopenia, and thrombocytopenia. It states that the findings revealed myelodysplastic syndrome where peripheral blood smear showed neutrophils with abnormal bilobed nuclei but normal cytoplasmic granularity.
ACCESSION #
31953650

 

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