Ocular vestibular evoked myogenic potentials in superior canal dehiscence

Rosengren, S. M.; Aw, S. T.; Halmagyi, G. M.; Todd, N. P. McAngus; Colebatch, J. G.
May 2008
Journal of Neurology, Neurosurgery & Psychiatry;May2008, Vol. 79 Issue 5, p559
Academic Journal
Objective: Patients with superior canal dehiscence (SCD) have large sound-evoked vestibular reflexes with pathologically low threshold. We wished to determine whether a recently discovered measure of the vestibulo-ocular reflex--the ocular vestibular evoked myogenic potential (OVEMP)--produced similar high-amplitude, low-threshold responses in SCD, and could differentiate patients with SCD from normal control patients. Methods: Nine patients with CT-confirmed SCD and 10 normal controls were stimulated with 500 Hz, 2 ms tone bursts and 0.1 ms clicks at intensities up to 142 dB peak SPL. Conventional VEMPs were recorded from the ipsilateral sternocleidomastoid muscle to determine threshold, and OVEMPs were recorded from electrode pairs placed superior and inferior to the eyes. Three-dimensional eye movements were measured with scleral dual-search coils. Results: In patients with SCD, OVEMP amplitudes were significantly larger than normal (p<0.001) and thresholds were pathologically low. The n10 OVEMP in the contralateral inferior electrode became particularly large with increasing stimulus intensity (up to 25 μV) and with up-gaze (up to 40 μV). Sound-evoked (slow-phase) eye movements were present in all patients with SCD (vertical: upward; torsional: upper pole away from the affected side; and horizontal: towards or away from the affected side), but began only as the OVEMP response became maximal, which is consistent with the surface potentials being produced by activation of the extraocular muscles that generated the eye movements. Conclusions: OVEMP amplitude and threshold (particularly the contralateral inferior n10 response) differentiated patients with SCD from normal controls. Our findings suggest that both the OVEMPs and induced eye movements in SCD are a result of intense saccular activation in addition to superior canal stimulation.


Related Articles

  • A case of Cronkhite-Canada syndrome with vestibular disturbances. Naoshima-Ishibashi, Yasuko; Murofushi, Toshihisa // European Archives of Oto-Rhino-Laryngology;Nov2004, Vol. 261 Issue 10, p558 

    A 66-year-old Japanese man with Cronkhite-Canada syndrome (CCS) presented with complaints of long-lasting dysequilibrium. On neuro-otological examination, he showed gaze-evoked nystagmus at the rightward and leftward gaze, and saccadic pursuit. On the caloric test, he showed no response in...

  • Discharge of pursuit-related neurons in the caudal part of the frontal eye fields in juvenile monkeys with up—down pursuit asymmetry. Kurkin, Sergei; Akao, Teppei; Fukushima, Junko; Fukushima, Kikuro // Experimental Brain Research;Feb2009, Vol. 193 Issue 2, p181 

    The smooth-pursuit system uses retinal image-slip-velocity information of target motion to match eye velocity to actual target velocity. The caudal part of the frontal eye fields (FEF) contains neurons whose activity is related to direction and velocity of smooth-pursuit eye movements (pursuit...

  • VEP Responses to Op-Art Stimuli. O’Hare, Louise; Clarke, Alasdair D. F.; Pollux, Petra M. J. // PLoS ONE;09/30/2015, Vol. 10 Issue 10, p1 

    Several types of striped patterns have been reported to cause adverse sensations described as visual discomfort. Previous research using op-art-based stimuli has demonstrated that spurious eye movement signals can cause the experience of illusory motion, or shimmering effects, which might be...

  • The Suppression of Reflexive Visual and Auditory Orienting When Attention Is Otherwise Engaged. Santangelo, Valerio; Belardinelli, Marta Olivetti; Spence, Charles // Journal of Experimental Psychology. Human Perception & Performan;Feb2007, Vol. 33 Issue 1, p137 

    Two experiments were conducted to examine whether abrupt onsets are capable of reflexively capturing attention when they occur outside the current focus of spatial attention, as would be expected if exogenous orienting operates in a truly automatic fashion. The authors established a highly...

  • Linearity of canal-otolith interaction during eccentric rotation in humans. Seidman, S.H.; Paige, G.D.; Tomlinson, R.D.; Schmitt, N. // Experimental Brain Research;Nov2002, Vol. 147 Issue 1, p29 

    During natural behavior, the head may simultaneously undergo rotation, transduced by the semicircular canals, and translation, transduced by the otolith organs. It has been demonstrated in monkey that the vestibulo-ocular reflexes (VORs) elicited by both endorgans (i.e., the angular and linear...

  • Inhibition of return in saccadic eye movements. Ro, Tony; Pratt, Jay; Rafal, Robert D. // Experimental Brain Research;Jan2000, Vol. 130 Issue 2, p264 

    Inhibition of return (IOR) is a phenomenon in which responses generated to targets at previously attended locations are delayed. It has been suggested that IOR affords a mechanism for optimizing the inspection of novel locations and that it is generated by oculomotor reflexes mediated by the...

  • Eye-head coordination in the guinea pig II. Responses to self-generated (voluntary) head movements. Shanidze, N.; Kim, A. H.; Loewenstein, S.; Raphael, Y.; King, W. M. // Experimental Brain Research;Sep2010, Vol. 205 Issue 4, p445 

    Retinal image stability is essential for vision but may be degraded by head movements. The vestibulo-ocular reflex (VOR) compensates for passive perturbations of head position and is usually assumed to be the major neural mechanism for ocular stability. During our recent investigation of...

  • Eye–head coordination in the guinea pig I. Responses to passive whole-body rotations. Shanidze, N.; Kim, A. H.; Raphael, Y.; King, W. M. // Experimental Brain Research;Sep2010, Vol. 205 Issue 3, p395 

    Vestibular reflexes act to stabilize the head and eyes in space during locomotion. Head stability is essential for postural control, whereas retinal image stability enhances visual acuity and may be essential for an animal to distinguish self-motion from that of an object in the environment....

  • Saccadic remapping of object-selective information. Wolfe, Benjamin; Whitney, David // Attention, Perception & Psychophysics;Oct2015, Vol. 77 Issue 7, p2260 

    Saccadic remapping, a presaccadic increase in neural activity when a saccade is about to bring an object into a neuron's receptive field, may be crucial for our perception of a stable world. Studies of perception and saccadic remapping, like ours, focus on the presaccadic acquisition of...


Read the Article


Sign out of this library

Other Topics