TITLE

HIF1α in hypoxia

AUTHOR(S)
McLaughlin, Kris
PUB. DATE
April 2008
SOURCE
Thorax;Apr2008, Vol. 63 Issue 4, p311
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article reports on a study which examines the physiological consequences of small ubiquitin-related modifier proteins (SUMO), particularly those related to hypoxia-inducible factor 1α (SENP1). The study also focuses on the biological consequences of SUMOylation and deSUMOylation in mammals.
ACCESSION #
31887369

 

Related Articles

  • Arkadia amplifies TGF-β superfamily signalling through degradation of Smad7. Daizo Koinuma; Masahiko Shinozaki; Akiyoshi Komuro; Kouichiro Goto; Masao Saitoh; Aki Hanyu; Masahito Ebina; Toshihiro Nukiwa; Keiji Miyazawa; Takeshi Imamura; Kohei Miyazono // EMBO Journal;12/15/2003, Vol. 22 Issue 24, p6458 

    Arkadia was originally identified as a protein that enhances signalling activity of Nodal and induces mammalian nodes during early embryogenesis; however, the mechanisms by which Arkadia affects transforming growth factor-β (TGF-β) superfamily signalling have not been determined. Here we...

  • Gains of ubiquitylation sites in highly conserved proteins in the human lineage. Dong Seon Kim; Yoonsoo Hahn // BMC Bioinformatics;2012, Vol. 13 Issue 1, p1 

    Background: Post-translational modification of lysine residues of specific proteins by ubiquitin modulates the degradation, localization, and activity of these target proteins. Here, we identified gains of ubiquitylation sites in highly conserved regions of human proteins that occurred during...

  • The power of SUMO. Smallridge, Rachel // Nature Reviews Molecular Cell Biology;Feb2006, Vol. 7 Issue 2, p78 

    The article discusses research on the covalent modification of proteins with small ubiquitin-like modifier (SUMO). Dejean and colleagues have studies the role of the SUMO pathway in mammals. They found mitotic chromosomal defects in blastocytes. They also examined the integrity of nuclear and...

  • Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud, Avinash; Alberts, Philipp; Amsen, Eva M.; Xuejian Xiong; Wasmuth, James; Saadon, Zachary; Fladd, Chris; Parkinson, John; Rotin, Daniela // Molecular Systems Biology;2009, Vol. 5 Issue 1, p333 

    Target recognition by the ubiquitin system is mediated by E3 ubiquitin ligases. Nedd4 family members are E3 ligases comprised of a C2 domain, 2–4 WW domains that bind PY motifs (L/PPxY) and a ubiquitin ligase HECT domain. The nine Nedd4 family proteins in mammals include two close...

  • VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1a. Li, Zaibo; Wang, Dakun; Messing, Edward M.; Wu, Guan // EMBO Reports;Apr2005, Vol. 6 Issue 4, p373 

    Hypoxia-inducible factor (HIF)-1ais a short-lived protein and is ubiquitinated and degraded through the von Hippel-Lindau protein (pVHL)-E3 ubiquitin ligase pathway at normoxia. Deubiquitination, by reversing ubiquitination, has been recognized as an important regulatory step in...

  • Role of the NEDD8 Modification of Cul2 in the Sequential Activation of ECV Complex. Sufan, Roxana I.; Ohh, Michael 1 // Neoplasia;Nov2006, Vol. 8 Issue 11, p956 

    ECV is an E3 ubiquitin ligase complex, which is composed of elongins B and C, Rbx1, Cul2, and the substrate-conferring von Hippel-Lindau (VHL) tumor-suppressor protein that targets the catalytic α subunit of hypoxia-inducible factor (HIF) for oxygen-dependent ubiquitin-mediated destruction....

  • From the editors.  // Nature Reviews Molecular Cell Biology;Jun2009, Vol. 10 Issue 6, p365 

    The article introduces the issue, which focuses on ubiquitylation of proteins, including articles on the HECT family of ligases, the 26S proteasome system in the plant kingdom, and the function of unconventional polyubiquitin chains.

  • Regulation of Cullin RING E3 Ubiquitin Ligases by CAND1 In Vivo. Yee Shin Chua; Boon Kim Boh; Ponyeam, Wanpen; Hagen, Thilo // PLoS ONE;2011, Vol. 6 Issue 1, p1 

    Cullin RING ligases are multi-subunit complexes consisting of a cullin protein which forms a scaffold onto which the RING protein Rbx1/2 and substrate receptor subunits assemble. CAND1, which binds to cullins that are not conjugated with Nedd8 and not associated with substrate receptors, has...

  • The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. Kwon-Yul Ryu; Maehr, René; Gilchrist, Catherine A.; Long, Michael A.; Bouley, Donna M.; Mueller, Britta; Ploegh, Hidde L.; Kopito, Ron R. // EMBO Journal;6/7/2007, Vol. 26 Issue 11, p2693 

    UbC is one of two stress-inducible polyubiquitin genes in mammals and is thought to supplement the constitutive UbA genes in maintaining cellular ubiquitin (Ub) levels during episodes of cellular stress. We have generated mice harboring a targeted disruption of the UbC gene. UbC−/−...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics