TITLE

cAMP and cGMP in nasal mucus related to severity of smell loss in patients with smell dysfunction

AUTHOR(S)
Henkin, R. I.; Velicu, I.
PUB. DATE
April 2008
SOURCE
Clinical & Investigative Medicine;Apr2008, Vol. 31 Issue 2, pE78
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: To evaluate nasal mucus levels of cAMP and cGMP in patients with taste and smell dysfunction with respect to severity of their smell loss. Methods: cAMP and cGMP were measured in nasal mucus using a sensitive spectrophotometric 96 plate ELISA technique. Smell loss was measured in patients with taste and smell dysfunction by standardized psychophysical measurements of olfactory function and classified by severity of loss into four types from most severe to least severe such that anosmia > Type I hyposmia > Type II hyposmia > Type III hyposmia. Measurements of nasal mucus cyclic nucleotides and smell loss were made independently. Results: As smell loss severity increased stepwise cAMP and cGMP levels decreased stepwise [cAMP, cGMP (in pmol/ml); anosmia - 0.004, 0.008: Type I hyposmia - 0.12±0.03, 0.10±0.03: Type II hyposmia - 0.15±0.02, 0.16±0.01: Type III hyposmia - 0.23±0.05, 0.20±0.15]. Conclusions: These results confirm the association of biochemical changes in cyclic nucleotides with systematic losses of smell acuity. These results confirm the usefulness of the psychophysical methods we defined to determine the systematic classification of smell loss severity. These changes can form the basis for the biochemical definition of smell loss among some patients with smell loss as well as for their therapy.
ACCESSION #
31872262

 

Related Articles

  • The effect of high altitude on olfactory functions. Altundağ, Aytuğ; Salihoglu, Murat; Çayönü, Melih; Cingi, Cemal; Tekeli, Hakan; Hummel, Thomas // European Archives of Oto-Rhino-Laryngology;Mar2014, Vol. 271 Issue 3, p615 

    It is known that high-altitude trips cause nasal congestion, impaired nasal mucociliary transport rate, and increased nasal resistance, due to decreased partial oxygen pressure and dry air. It is also known that olfactory perception is affected by barometric pressure and humidity. The aim of the...

  • Rhinocerebral mucormycosis: pathways of spread. Hosseini, Seid; Borghei, Peyman // European Archives of Oto-Rhino-Laryngology;Dec2005, Vol. 262 Issue 11, p932 

    Rhinocerebral mucormycosis is an invasive, opportunistic fungal infection usually seen in immunocompromised patients, and particularly in the setting of diabetes or immune deficiency. It is assumed that the port of entry is colonization of the nasal mucosa, allowing the fungus to spread via the...

  • Intrinsic chemosensory signal recorded from the human nasal mucosa in patients with smell loss. Ishimaru, Tadashi; Krone, Franziska; Scheibe, Mandy; Gudziol, Volker; Negoias, Simona; Hummel, Thomas // European Archives of Oto-Rhino-Laryngology;Apr2013, Vol. 270 Issue 4, p1335 

    Physiological investigation of olfactory receptor function in hyposmic or anosmic patients is rare. Pioneers examined the electro-olfactogram in patients with olfactory disturbance. Although the electro-olfactogram is an established method to record olfactory responses from human olfactory...

  • Olfactory bulb volume in patients with sinonasal disease. Rombaux, Philippe; Potier, Helene; Bertrand, Bernard; Duprez, Thierry; Hummel, Thomas // American Journal of Rhinology;Nov/Dec2008, Vol. 22 Issue 6, p598 

    Background: The aim of this study was to assess the volume of the olfactory bulb (OB) in patients with chronic rhinosinusitis (without nasal polyposis at the endoscopic evaluation) and to evaluate the correlation between this measure and the degree of sinonasal inflammation. Methods: Patients...

  • Paradoxical nasal obstruction: Analysis of characteristics using acoustic rhinometry. Hyo Yeol Kim; Hun-Jong Dhong; Sang Duk Hong; Hyun Jong Lee; Hyun Jin Cho; Seung Kyu Chung // American Journal of Rhinology;Jul/Aug2007, Vol. 21 Issue 4, p408 

    Background: The aim of this study was to determine the characteristics of acoustic rhinometric parameters in patients with paradoxical nasal obstruction. Methods: The medical records of 1844 patients who had nasal septal deviation between 1998 and 2004 at our institute were assessed...

  • Thresholds in Nasal Histamine Challenge in Patients with Allergic Rhinitis, Patients with Hyperreflectory Rhinopathy, and Healthy Volunteers. Wuestenberg, Eike G.; Hauswald, Bettina; Huettenbrink, Kari-Bernd // American Journal of Rhinology;Nov/Dec2004, Vol. 18 Issue 6, p371 

    Background: Characteristic symptoms of hyperreflectory rhinopathy include recurrent sneezing, nasal obstruction, and nasal secretion without an allergic background. The diagnosis can only be made if all differential diagnoses have been excluded. So far no clinical test has been established to...

  • Analiza postÄ™powania diagnostycznego i terapeutycznego w pourazowych krwawieniach n nosa. Bruzgielewicz, Antoni; Osuch-Wójcikiewicz, Ewa; Niemczyk, Kazimierz; Bartoszewicz, Robert; Kozłowska, Katarzyna // Otorynolaryngologia;Jun2007, Vol. 6 Issue 2, p88 

    Introduction. Epistaxis after craniofacial trauma is a serious diagnostic and therapeutic problem due to its abundance and recurrent character. Aim. The objective of this retrospective study was to analyse diagnostic and therapeutic management of patients referred to our ENT clinic for profuse,...

  • Perennial rhinitis. Saleh, Hesham A.; Durham, Stephen R. // BMJ: British Medical Journal (International Edition);9/8/2007, Vol. 335 Issue 7618, p502 

    The article presents an overview of perennial rhinitis, which is defined clinically as an inflammatory condition of the nose characterized by nasal obstruction, sneezing, itching, or rhinorrhea, occurring for an hour or more on most days throughout the year. A discussion of the diagnosis of...

  • Olfactory mucosa histological findings in laryngectomees. Miani, Cesare; Ortolani, Fulvia; Bracale, Anna Maria Bergamin; Petrelli, Lucia; Staffieri, Alberto; Marchini, Maurizio // European Archives of Oto-Rhino-Laryngology;Nov2003, Vol. 260 Issue 10, p529 

    After total laryngectomy, the patients often report immediate and marked olfactory deficit. The aim of this study was to determine whether hyposmia in laryngectomees reflects olfactory epithelial damage. Ten laryngectomized patients and ten rhinologically normal subjects were subjected to...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics