Beta news for pancreatic stem cells

January 2008
Australian Life Scientist;1/29/2008, p1
Elusive pancreatic stem cells found in adult mice, Belgian researchers say.


Related Articles

  • Dickkopf-3 is expressed in a subset of adult human pancreatic beta cells. Hermann, M.; Pirkebner, D.; Draxl, A.; Berger, P.; Untergasser, G.; Margreiter, R.; Hengster, P. // Histochemistry & Cell Biology;May2007, Vol. 127 Issue 5, p513 

    The Dickkopf (Dkk) gene family of secretory modulators of canonical Wnt/beta catenin signals is involved in the control of stem cell proliferation, homeostasis and differentiation. Bioinformatic data on dkk-1/3 gene expression, indicating high expression levels in the human pancreas, led us to...

  • Regenerative medicine: Self-help for insulin cells. Zaret, Ken // Nature;5/6/2004, Vol. 429 Issue 6987, p30 

    Examines the mechanisms in the production of β-cells in human pancreatic tissue. Relation of various stem-cell types with the appearance of new β-cells; Stability in the percentage of marked β-cells during both normal turnover and pancreatic regeneration; Identification of human...

  • The role of calcium/calmodulin-dependent protein kinase cascade in glucose upregulation of insulin gene expression. Yu, Xiao; Murao, Koji; Sayo, Yoshitaka; Imachi, Hitomi; Cao, Wen M.; Ohtsuka, Shouji; Niimi, Michio; Tokumitsu, Hiroshi; Inuzuka, Hiroyuki; Wong, Norman C.W.; Kobayashi, Ryoji; Ishida, Toshihiko // Diabetes;Jun2004, Vol. 53 Issue 6, p1475 

    A number of factors have been reported to affect insulin synthesis in beta-cells. Although glucose is the most important regulator of insulin gene expression in pancreatic beta-cells, the mechanisms whereby glucose stimulates insulin gene transcription in response to changes in glucose...

  • The Transcriptional Co-Regulator HCF-1 Is Required for INS-1 β-cell Glucose-Stimulated Insulin Secretion. Iwata, Terri N.; Cowley, Timothy J.; Sloma, Michael; Ji, Yewei; Kim, Hana; Qi, Ling; Lee, Siu Sylvia // PLoS ONE;Nov2013, Vol. 8 Issue 11, p1 

    The transcriptional co-regulator host cell factor-1 (HCF-1) plays critical roles in promoting cell cycle progression in diverse cell types, and in maintaining self-renewal of embryonic stem cells, but its role in pancreatic β-cell function has not been investigated. Immunhistochemistry of...

  • Gene Expression Profiling of Mouse Embryonic Stem Cell Progeny Differentiated by Lumelsky’s Protocol. Kitano, Mami; Kakinuma, Michiru; Takatori, Atsushi; Negishi, Takayuki; Ishii, Yoshiyuki; Kyuwa, Shigeru; Yoshikawa, Yasuhiro // Cells Tissues Organs;2006, Vol. 183 Issue 1, p24 

    Successful conversion of embryonic stem (ES) cells into insulin-producing cells has been reported by Lumelsky et al. (Science 2001;292:1389–1394); however, it remains controversial. In this study, we investigated the properties of ES cell progeny-induced differentiation according to...

  • ALDH Expression Characterizes G1-Phase Proliferating Beta Cells during Pregnancy. Zhang, Lijuan; Wang, Lin; Liu, Xiaoliang; Zheng, Dongming; Liu, Sishi; Liu, Caixia // PLoS ONE;May2014, Vol. 9 Issue 5, p1 

    High levels of aldehyde dehydrogenase (ALDH) activity have been detected in various progenitor and stem cells. Thus, Aldefluor fluorescence, which represents precisely the ALDH activity, has been widely used for the identification, evaluation, and isolation of stem and progenitor cells....

  • Human Pancreatic Islet-Derived Precursor Cells Display Mesenchymal Stem Cell Features and Differentiation Capacity. Limbert, Catarina; Jakob, Franz; Päth, Günter; Niu, Xinjie; Ebert, Regina; Brendel, Mathias D.; Bretzel, Reinhard G.; Seufert, Jochen // Diabetes;Jun2007 Supplement 1, Vol. 56, pA427 

    Strategies for cell based-therapy of type 1 diabetes mellitus are based on pancreatic islet replacement and islet regeneration. Human islet-derived precursor cells (hIPC) expressing nestin and c-met have been investigated as an additional source of beta-cells. These cells have been demonstrated...

  • Urocortin 3 Marks Mature Human Primary and Embryonic Stem Cell-Derived Pancreatic Alpha and Beta Cells. van der Meulen, Talitha; Ruiyu Xie; Kelly, Olivia G.; Vale, Wylie W.; Sander, Maike; Huising, Mark O. // PLoS ONE;Dec2012, Vol. 7 Issue 12, p1 

    The peptide hormone Urocortin 3 (Ucn 3) is abundantly and exclusively expressed in mouse pancreatic beta cells where it regulates insulin secretion. Here we demonstrate that Ucn 3 first appears at embryonic day (E) 17.5 and, from approximately postnatal day (p) 7 and onwards throughout adult...

  • Gastrin Stimulates β-Cell Neogenesis and Increases Islet Mass From Transdifferentiated but Not From Normal Exocrine Pancreas Tissue. Rooman, Ilse; Lardon, Jessy; Bouwens, Luc // Diabetes;Mar2002, Vol. 51 Issue 3, p686 

    It is still unclear which factors regulate pancreatic regeneration and β-cell neogenesis and which precursor cells are involved. We evaluated the role of intravenously infused gastrin in regenerating pancreas of duct-ligated rats. The ligation of exocrine ducts draining the splenic half of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics