TITLE

Estrogen replacement regimen and brain infusion of lipopolysaccharide differentially alter steroid receptor expression in the uterus and hypothalamus

AUTHOR(S)
L. Marriott; K. McGann-Gramling; B. Hauss-Wegrzyniak; L. Sheldahl; R. Shapiro; D. Dorsa; G. Wenk
PUB. DATE
December 2007
SOURCE
Endocrine (1355008X);Dec2007, Vol. 32 Issue 3, p317
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  The regimen of estrogen replacement can alter the consequences of estrogen therapy and stressors. To determine the long-term effects and interaction of these systems on the brain and periphery, adult female rats were infused with lipopolysaccharide (LPS) into the fourth ventricle of the brain for 4 weeks, and ovariectomized rats were administered either constant or pulsed regimens of estrogen replacement (17β-estradiol) until sacrifice at 8 weeks. Constant, but not pulsed, estrogen replacement reduced ERα and increased HSP90, HSP70, and PRB uterine protein levels. Both estrogen regimens increased ERβ, HSP27, and PRA uterine proteins. Both regimens reduced hypothalamic levels of ERα, but not ERβ, HSP, or PR. No changes were observed in the hippocampus. Long-term brain infusion of LPS activated microglia and reduced body weight, but did not alter corticosterone or nitrotyrosine levels. LPS infusion into intact rats suppressed uterine weight, increased ERα and decreased HSP90 in the uterus. LPS did not alter uterine weight in ovariectomized rats treated with constant or pulsed estrogen. Together, these data suggest the timing of estrogen replacement and neuroinflammatory stressors can profoundly affect uterine and hypothalamic steroid receptor expression and may be important parameters to consider in the post-menopausal intervention with estrogen.
ACCESSION #
31864457

 

Related Articles

  • Androgen modulation of social decision-making mechanisms in the brain: an integrative and embodied perspective. Oliveira, Gonçalo A.; Oliveira, Rui F.; Somoza, Gustavo M.; Maruska, Karen P. // Frontiers in Neuroscience;Jul2014, p1 

    Apart from their role in reproduction androgens also respond to social challenges and this response has been seen as a way to regulate the expression of behavior according to the perceived social environment (Challenge hypothesis, Wingfield et al., 1990). This hypothesis implies that social...

  • Developmental expression of MNAR mRNA in the mouse brain. Pawlak, Justyna; Beyer, Cordian // Cell & Tissue Research;Jun2005, Vol. 320 Issue 3, p545 

    During the development of the central nervous system, estrogen influences cellular differentiation and determines the functional connectivity of distinct neural networks. Estrogens generally act through nuclear estrogen receptors (ERs). Recent research has additionally revealed rapid estrogen...

  • Estrogen receptor beta (ERβ) is expressed in brain astrocytic tumors and declines with dedifferentiation of the neoplasm. Batistatou, Anna; Stefanou, Dimitrious; Goussia, Anna; Arkoumani, Evdokia; Papavassiliou, Athanasios G.; Agnantis, Niki J. // Journal of Cancer Research & Clinical Oncology;Jul2004, Vol. 130 Issue 7, p405 

    Purpose. Estrogen receptor β (ERβ) is the second identified receptor mediating the effects of estrogen on target tissues. The role of ERβ in cancer pathobiology is largely unknown, because specific antibodies have not been available until recently. Initial studies have shown that ERβ...

  • BRAIN POWER. Weir, Kirsten // Current Health 1;Sep2005, Vol. 29 Issue 1, p16 

    Discusses the power of a human brain.

  • Meet Your Incredible Brain. Kukula, Kathy // Junior Scholastic;10/4/2002, Vol. 105 Issue 3, Following p16 

    Discusses various functions performed by human brain.

  • New Windows on Our Minds. Dingman, C.W. // Highlights for Children;Apr2002, Vol. 57 Issue 4, p36 

    Presents information on how the human brain works.

  • Preface. Yevich, Joseph P.; Smith, David W. // Current Pharmaceutical Design;Mar2003, Vol. 9 Issue 8, p1 

    Presents an overview of research articles on brain processes published in March 15, 2003, issue of the 'Current Pharmaceutical Design' periodical. Key issues of interest; Analysis of pertinent topics and relevant issues; Implications on studies of pharmaceutical design.

  • EXERCISE YOUR BRAIN. Umansky, Diane // Good Housekeeping;Apr2002, Vol. 234 Issue 4, p58 

    Presents ways to cross-train a person's brain.

  • Build Your Brain! Fields, R. Douglas // Odyssey;Mar2011, Vol. 20 Issue 3, p42 

    The article presents information related to brain formation and development.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics