Interleukin-18 enhances glucose uptake in 3T3-L1 adipocytes

Yi-Sheng Yang; Xiao-Ying Li; Jie Hong; Wei-Qiong Gu; Yi-Fei Zhang; Jun Yang; Huai-Dong Song; Jia-Lun Chen; Guang Ning
December 2007
Endocrine (1355008X);Dec2007, Vol. 32 Issue 3, p297
Academic Journal
Abstract  In order to characterize the potential causative effects of interleukin-18 (IL-18) on insulin resistance, we measured glucose uptake in 3T3-L1 adipocytes treated with mouse recombinant IL-18. IL-18 surprisingly enhanced, rather than reduced insulin-mediated glucose uptake in adipocytes. Moreover IL-18 could counteract the glucose uptake suppression caused by tumor necrosis factor α in 3T3-L1 adipocytes. The mechanism dissection showed that the IL-18 upregulated phosphorylated Akt and downregulated phosphorylated P38 MAPK. These findings indicated that the elevated serum IL-18 levels in obesity and diabetes might be a compensatory response to insulin resistance.


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