TITLE

Interleukin-18 enhances glucose uptake in 3T3-L1 adipocytes

AUTHOR(S)
Yi-Sheng Yang; Xiao-Ying Li; Jie Hong; Wei-Qiong Gu; Yi-Fei Zhang; Jun Yang; Huai-Dong Song; Jia-Lun Chen; Guang Ning
PUB. DATE
December 2007
SOURCE
Endocrine (1355008X);Dec2007, Vol. 32 Issue 3, p297
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  In order to characterize the potential causative effects of interleukin-18 (IL-18) on insulin resistance, we measured glucose uptake in 3T3-L1 adipocytes treated with mouse recombinant IL-18. IL-18 surprisingly enhanced, rather than reduced insulin-mediated glucose uptake in adipocytes. Moreover IL-18 could counteract the glucose uptake suppression caused by tumor necrosis factor α in 3T3-L1 adipocytes. The mechanism dissection showed that the IL-18 upregulated phosphorylated Akt and downregulated phosphorylated P38 MAPK. These findings indicated that the elevated serum IL-18 levels in obesity and diabetes might be a compensatory response to insulin resistance.
ACCESSION #
31864454

 

Related Articles

  • A Modified Protocol to Maximize Differentiation of Human Preadipocytes and Improve Metabolic Phenotypes. Lee, Mi-Jeong; Wu, Yuanyuan; Fried, Susan K. // Obesity (19307381);Dec2012, Vol. 20 Issue 12, p2334 

    Adipose stromal cells proliferate and differentiate into adipocytes, providing a valuable model system for studies of adipocyte biology. We compared differentiation protocols for human preadipocytes and report on their metabolic phenotypes. By simply prolonging the adipogenic induction period...

  • IL-6 induces lipolysis and mitochondrial dysfunction, but does not affect insulin-mediated glucose transport in 3T3-L1 adipocytes. Ji, Chenbo; Chen, Xiaohui; Gao, Chunlin; Jiao, Liuhong; Wang, Jianguo; Xu, Guangfeng; Fu, Hailong; Guo, Xirong; Zhao, Yaping // Journal of Bioenergetics & Biomembranes;Aug2011, Vol. 43 Issue 4, p367 

    Interleukin-6 (IL-6) has emerged as an important cytokine involved in the regulation of metabolism. However, the role of IL-6 in the etiology of obesity and insulin resistance is not fully understood. Mitochondria are key organelles of energy metabolism, and there is growing evidence that...

  • Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes. Shunming Zhu; Fei Sun; Weijie Li; Yanjie Cao; Chen Wang; Yabin Wang; Dong Liang; Rongqing Zhang; Shenwei Zhang; Haichang Wang; Feng Cao // Molecular & Cellular Biochemistry;Jul2011, Vol. 353 Issue 1/2, p305 

    pelin, a cytokine mainly secreted by adipocytes, is closely related with insulin resistance. The underlying molecular mechanisms of how apelin affects insulin resistance, however, are poorly understood. This study aimed to investigate the effect of apelin on glucose metabolism and insulin...

  • Humoral Regulation of Resistin Expression in 2T2-L1 and Mouse Adipose Cells. Shojima, Nobuhiro; Sakoda, Hideyuki; Ogihara, Takehide; Fujishiro, Midori; Katagiri, Hideki; Anai, Motonobu; Onishi, Yukiko; Ono, Hiraku; Inukai, Kouichi; Abe, Miho; Fukushima, Yasushi; Kikuchi, Masatoshi; Oka, Yoshitomo; Asano, Tomoichiro // Diabetes;Jun2002, Vol. 51 Issue 6, p1737 

    Resistin is a hormone secreted by adipocytes that acts on skeletal muscle myocytes, hepatocytes, and adipocytes themselves, reducing their sensitivity to insulin. In the present study, we investigated how the expression of resistin is affected by glucose and by mediators known to affect insulin...

  • Erratum to: Stearoyl-CoA desaturase enzyme 1 inhibition reduces glucose utilization for de novo fatty acid synthesis and cell proliferation in 3T3-L1 adipocytes. Yee, Jennifer; Wahjudi, Paulin; Vega, Juan; Lim, Shu; Martin, Ashley; Patterson, Mary; Cohen, Joshua; Mao, Catherine; Lee, Wai-Nang // Metabolomics;Aug2013, Vol. 9 Issue 4, p817 

    A correction to the article "Stearoyl-Coa Desaturase Enzyme 1 Inhibition Reduces Glucose Utilization for de Novo Fatty Acid Synthesis and Cell Proliferation in 3T3-L1 Adipocytes" that was published in the April 17, 2013 issue is presented.

  • Development of insulin-responsive glucose uptake and GLUT4 expression in differentiating human adipocyte precursor cells. Hauner, H; Röhrig, K; Spelleken, M; Liu, L S; Eckel, J // International Journal of Obesity & Related Metabolic Disorders;May1998, Vol. 22 Issue 5, p448 

    OBJECTIVE: In differentiating human preadipocytes glucose uptake in the presence of insulin is a prerequisite for lipid accumulation. The aim of this study was to characterize the insulin-regulated glucose transport system during and after differentiation. DESIGN AND METHODS: Human adipocyte...

  • ER stress in adipocytes and insulin resistance: Mechanisms and significance (Review). SHAHZAD KHAN; CHANG HUA WANG // Molecular Medicine Reports;2014, Vol. 10 Issue 5, p2234 

    Adipose tissue (AT) has numerous important functions within the body. Of particular importance is its role as an endocrine organ in the control of whole-body glucose and lipid metabolism, which is achieved by the secretion of various proteins. Among these proteins are adipokines, such as...

  • Tipping the Balance in Metabolic Regulation: Regulating Regulatory T Cells by Costimulation. Ling Qi // Diabetes;Apr2014, Vol. 63 Issue 4, p1179 

    The author reflects on the relationship between obesity and systemic low-grade chronic inflammation, and how the immune system reacts to obesity and its ability to reach self-tolerance while driving back foreign pathogens. He discusses the function of T lymphocytes and immunosuppressive...

  • Endocrinology & metabolism.  // Clinical & Investigative Medicine;Aug97 Supplement, Vol. 20, pS18 

    Presents an abstract of the research manuscript `Interleukin-1beta-converting enzyme (ICE) expression and apoptosis in adipocytes,' by G. Shillabeer, E. Tibbo et al from the University of Ottawa.

Share

Read the Article

Courtesy of NEW JERSEY STATE LIBRARY

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics