Effects of active immunization against cholecystokinin 8 on performance, contents of serum hormones, and expressions of CCK gene and CCK receptor gene in pigs

Keying Zhang; Zhongbiao Yuan; Yu Bing; Xiaoling Chen; Xuemei Ding; Daiwen Chen
December 2007
Endocrine (1355008X);Dec2007, Vol. 32 Issue 3, p338
Academic Journal
Abstract  This study was conducted to investigate the effects of active immunization against cholecystokinin 8 (CCK8) on the content of serum CCK, expression of CCK, and CCK receptor gene in pigs. The subjects for this experiment were 15 pigs divided into three groups (5 pigs per group). The treated groups were immunized with CCK8 conjugated to human serum albumin (HSA). The control group was immunized with same dosage of HSA. The average daily gain of pig fed with 250 μg CCK was significantly increased (P 8, insulin, and leptin in serum was significantly (P 8 antibody was significantly (P P 8 could increase the content of CCK antibody and suppress CCK gene and CCK receptor gene expressions and in result improve feed intake and growth performance of pigs.


Related Articles

  • The Gastrointestinal Hormones, Secretin and Cholecystokinin-Pancreozymin. Jorpes, J. Erik; Mutt, Viktor // Annals of Internal Medicine;Sep61, Vol. 55 Issue 3, p395 

    Discusses the history of the gastrointestinal hormones. Strength of the clinical unit of secretin; Clinical use of cholecystokinin; Combined cholecystokinin secretin test.

  • Regulation of cholecystokinin secretion in humans. Liddle, Rodger A.; Liddle, R A // Journal of Gastroenterology;2000, Vol. 35 Issue 3, p181 

    Discusses the regulation of the gastrointestinal hormone cholecystokinin (CCK) secretion in humans. Definition of CCK; Description of CCK cells; Measurement of CCK; Dietary and neural regulation of CCK secretion; Nutrients or ingesta that regulate intestinal CCK release.

  • Selection and characterization of DARPins specific for the neurotensin receptor 1. Peter Milovnik; Davide Ferrari; Casim A. Sarkar; Andreas Plückthun // PEDS: Protein Engineering, Design & Selection;Jun2009, Vol. 22 Issue 6, p357 

    We describe here the selection and characterization of designed ankyrin repeat proteins (DARPins) that bind specifically to the rat neurotensin receptor 1 (NTR1), a G-protein coupled receptor (GPCR). The selection procedure using ribosome display and the initial clone analysis required <10 µg...

  • High-affinity Neurotensin Receptor is Involved in Phosphoinositide Turnover Increase by Inhibition of Sodium Pump in Neonatal Rat Brain. Susana Pereyra-Alfonso; María del Valle Armanino; Carolina Vázquez; Clara Peña // Neurochemical Research;Nov2008, Vol. 33 Issue 11, p2206 

    Abstract  Phosphoinositide (PI) metabolism is enhanced in neonatal brain by activation of neurotransmitter receptors and by inhibition of the sodium pump with ouabain or endogenous inhibitor termed endobain E. Peptide neurotensin inhibits synaptosomal membrane Na+, K+-ATPase activity, an...

  • Effects of endogenous cholecystokinin on gastric emptying and tolerance to a liquid volume load in humans. Thompson, David; Lal, Simon; McLaughlin, John; D'Amato, Massimo; Griffin, Patrick; Schneier, Harvey; Giacovelli, Giampaolo; Dockray, Graham; Varro, Andrea // American Journal of Gastroenterology;Sep2003 Supplement, Vol. 98, pS45 

    An abstract of the article "Effects of Endogenous Cholecystokinin on Gastric Emptying and Tolerance to a Liquid Volume Load in Humans," by David Thompson, Simon Lal, John McLaughlin, Massimo D'Amato, Patrick Griffin, Harvey Schneier, Giampaolo Giacovelli and colleagues is presented.

  • Description and application of a novel glucagon-like peptide-1 (GLP-1) radioimmunoassay. Lelesz, B.; Tóth, G.; Peitl, B.; Hegedűs, C.; Drimba, L.; Sári, R.; Szilvássy, Z.; Németh, J. // Journal of Radioanalytical & Nuclear Chemistry;Jan2014, Vol. 299 Issue 1, p157 

    The gut hormone glucagon-like peptide-1 (GLP-1) is derived from the transcription product of the proglucagon gene in the intestinal L cells. The known physiological functions of this peptide include: increases insulin and decreases glucagon secretion from the pancreas, furthermore promotes...

  • Heterogeneity of Cholecystokinin Receptors: A New Interest Towards the Development of CCK2 Agonists. Bellier, B.; Gigoux, V.; Garbay, C. // Current Medicinal Chemistry - Central Nervous System Agents;Nov2001, Vol. 1 Issue 3, p209 

    Cholecystokinin (CCK) is involved in essential physiological processes, through its interaction with two receptors (CCK1, CCK2). Numerous CCK2-selective agonists and antagonists have been synthesised however, the therapeutic interest for CCK2 ligands has remained focused on antagonists, endowed...

  • Influence of semax on the emotional state of white rats in the norm and against the background of cholecystokinin-tetrapeptide action. Levitskaya, N.; Vilenskii, D.; Sebentsova, E.; Andreeva, L.; Kamensky, A.; Myasoedov, N. // Biology Bulletin;Apr2010, Vol. 37 Issue 2, p186 

    The effects of the adrenocorticotropic hormone (ACTH(4–10)) analog, Semax (MEHFPGP), on the level of anxiety and depression in white rats have been studied in the normal state and against the back-ground of cholecystokinin-tetrapeptide (CCK-4) action. Semax was injected intranasally in...

  • Low Plasma Cholecystokinin Response after Ingestion of a Test Meal in Patients with Chronic Pancreatitis. Funakoshi, Akihiro; Nakano, Itsuro; Shinozaki, Hirotsugu; Ibayashi, Hiroshi; Tateishi, Kayoko; Hamaoka, Toshiyuki // American Journal of Gastroenterology;Dec1985, Vol. 80 Issue 12, p937 

    Postprandial responses of plasma cholecystokinin (CCK) in patients with severe chronic pancreatitis (n = 7) were studied. Plasma CCK level rose from 11.2 ± 1.8 pg/ml at the basal level to a maximum of 23.3 ± 3.0 pg/ml at 10 min after the ingestion of a liquid meal in healthy subjects (n =...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics