TITLE

Multiple facets of follicle-stimulating hormone receptor function

AUTHOR(S)
Alfredo Ulloa-Aguirre; Teresa Zariñán; Ana Pasapera; Patricia Casas-González; James Dias
PUB. DATE
December 2007
SOURCE
Endocrine (1355008X);Dec2007, Vol. 32 Issue 3, p251
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  Follicle-stimulating hormone (FSH) is a glycoprotein hormone produced by the anterior pituitary gland. This gonadotropin plays an essential role in reproduction. Its receptor (FSHR) belongs to the superfamily of G protein-coupled receptors (GPCR), specifically the family of rhodopsin-like receptors. Agonist binding to the FSHR triggers the rapid activation of multiple signaling cascades, mainly the cAMP–adenylyl cyclase–protein kinase A cascade, that impact diverse biological effects of FSH in the gonads. As in other G protein-coupled receptors, the several cytoplasmic domains of the FSHR are involved in signal transduction and termination of the FSH signal. Here we summarize some recent information on the signaling cascades activated by FSH as well as on the role of the intracytoplasmic domains of the FSHR in coupling to membrane and cytosolic proteins linked to key biological functions regulated by the FSH–FSHR system.
ACCESSION #
31864450

 

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