l -thyroxine therapy in Hashimoto’s thyroiditis patients with subclinical and overt hypothyroidism. Get access to over 12 million other articles!" />
TITLE

Coronary flow reserve after l -thyroxine therapy in Hashimoto’s thyroiditis patients with subclinical and overt hypothyroidism

AUTHOR(S)
Huseyin Oflaz; Ramazan Kurt; Fatma Sen; Imran Onur; Arif Cimen; Ali Elitok; Kultigin Turkmen; Burak Pamukcu; Erdem Kasikcioglu; Zehra Bugra; Fehmi Mercanoglu; Nese Ozbey
PUB. DATE
December 2007
SOURCE
Endocrine (1355008X);Dec2007, Vol. 32 Issue 3, p264
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract   Backgound/Aims Overt and subclinical hypothyroidism are reported to be associated with increased cardiovascular disease risk. We have used coronary flow reserve (CFR) measurement by trans-thoracic Doppler echocardiography (TTDE) to determine coronary microvascular function in Hashimoto’s thyroiditis patients with overt and subclinical hypothyroidism and to evaluate effects of l-thyroxine replacement on coronary endothelial function. Methods In total, 10 overt hypothyroid patients, 10 subclinical hypothyroid patients, and 10 controls were enrolled. FT4, TSH, anti-thyroid antibodies, lipid profile, insulin, glucose, HOMA-IR, physical parameters, and CFR measured by TTDE were recorded before and after 6 months of l-thyroxine replacement in all groups. Results CFR values of all hypothyroid patients at baseline were significantly lower than those in controls. After l-thyroxine, CFR increased significantly in overt and subclinical hypothyroidism with respect to the baseline measurements (P r = 0.31, P = 0.01) and negatively correlated with TSH and HOMA-IR (r = −0.38, P = 0.002 and r = −0.42, P Conclusion Subclinical as well as overt hypothyroid patients have impaired coronary microvascular function which improved after l-thyroxine therapy. Treatment of Hashimoto’s thyroiditis patients with subclinical hypothyroidism should be considered to improve cardiovascular disease risk.
ACCESSION #
31864448

 

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