Differentiated Thyroid Cancers 1120 mm in Diameter Have Clinical and Histopathologic Characteristics Suggesting Higher Aggressiveness than Those 10 mm

Roberta Rossi; Elio Roti; Giorgio Trasforini; Giancarlo Pansini; Luigi Cavazzini; Maria Chiara Zatelli; Elizabeth N. Pearce; Lewis E. Braverman; Ettore C. Degli Uberti
March 2008
Thyroid;Mar2008, Vol. 18 Issue 3, p309
Academic Journal
Objective:To compare characteristics and outcomes of differentiated thyroid cancers 10 mm with those 1120 mm in diameter.Design:Retrospective chart review of 426 patients with thyroid carcinoma 20 mm diagnosed and treated between 1990 and 2004 in one university clinic.Main outcomes:Lymph node metastases were more frequent at diagnosis in 1120 mm than in 10 mm cancers (p< 0.001). The prevalence of distant metastases did not differ between 10 mm and 1120 mm cancers. One hundred and thirty-three patients (73) with tumors 1120 mm were disease free 2 years after 131I treatment, and no recurrence has been observed over 214 years of follow-up. Forty-one patients (22) with cancers 1120 mm (N1 or M1) required 24 years to become disease free. Neck lymph node recurrence was observed in nine patients (4.9) 4 months to 14 years after surgery and 131I therapy. Four patients (1.6) with cancers 10 mm in diameter had cancer recurrence (p0.05 compared to the 1120 mm cancers). Based on the presence of distant metastases at diagnosis and recurrence of disease during follow-up, cancers 1120 mm in diameter seemed more aggressive than those 10 mm (p< 0.05).Conclusion:Cancers 1120 mm seem more aggressive than those 10 mm.


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