TITLE

Response of Combination Therapy on Viral Load and Disease Severity in Chronic Hepatitis C

AUTHOR(S)
Abdul Malik; Mohammad Asim; Anita Chakravarti; Rakha Das
PUB. DATE
April 2008
SOURCE
Digestive Diseases & Sciences;Apr2008, Vol. 53 Issue 4, p1107
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  Influence of genotypes on viral kinetics and disease severity in chronic hepatitis C (CH-C) patients has been implicated, but requires further investigation. The 41 HCV patients were genotyped by restriction fragment length polymorphism and included for 48 weeks of combination therapy on the basis of clinical (alanine amino transferase ≥60 IU/l) and histological features (histological activity index ≥3). A significant number (30/41) of patients (6/9 of genotype 1, 23/30 of genotype 3 and 1/2 of mixed genotype) attain sustained virological response despite high viral load at baseline. More aggressive treatment was required in genotype 1 than in genotype 3 due to slow response rate. Significant (P 
ACCESSION #
31851981

 

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