TITLE

Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults

AUTHOR(S)
Kekkonen, Riina A.; Lummela, Netta; Karjalainen, Heli; Latvala, Sinikka; Tynkkynen, Soile; Järvenpää, Salme; Kautiainen, Hannu; Julkunen, Ilkka; Vapaatalo, Heikki; Korpela, Riitta; Costa, Franceso
PUB. DATE
April 2008
SOURCE
World Journal of Gastroenterology;4/7/2008, Vol. 14 Issue 13, p2029
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
AIM: To evaluate the effects of three potentially anti-inflammatory probiotic bacteria from three different genera on immune variables in healthy adults in a clinical setting based on previous in vitro characterization of cytokine responses. METHODS: A total of 62 volunteers participated in this randomized, double-blind and placebo-controlled parallel group intervention study. The volunteers were randomized to receive a milk-based drink containing either Lactobacillus rhamnosus GG (LGG), Bifidobacterium animalis ssp. lactis Bb12 (Bb12), or Propionibacterium freudenreichii ssp. shermanii JS (PJS) or a placebo drink for 3 wk. Venous blood and saliva samples were taken at baseline and on d 1, 7 and 21. Fecal samples were collected at baseline and at the end of intervention. RESULTS: The serum hsCRP expressed as the median AUC0-21 (minus baseline) was 0.018 mg/L in the placebo group, -0.240 mg/L in the LGG group, 0.090 mg/L in the Bb12 group and -0.085 mg/L in the PJS group (P = 0.014). In vitro production of TNF-α from in vitro cultured peripheral blood mononuclear cells (PBMC) was significantly lower in subjects receiving LGG vs placebo. IL-2 production from PBMC in the Bb12 group was significantly lower compared with the other groups. CONCLUSION: In conclusion, probiotic bacteria have strain-specific anti-inflammatory effects in healthy adults.
ACCESSION #
31783859

 

Related Articles

  • Primed monocytes: putative culprits of chronic low-grade inflammation and impaired innate immune responses in patients on hemodialysis. Kim, Hye; Woo, Young; Yang, Ha; Choi, Hye; Jo, Sang; Cho, Won; Kim, Hyoung-Kyu // Clinical & Experimental Nephrology;Apr2011, Vol. 15 Issue 2, p258 

    Background: End-stage renal disease patients are known to be in a state of chronic low-grade inflammation and to have high infection-related morbidity and mortality. However, the precise mechanisms are not understood. The purpose of this study was to determine the mechanisms underlying chronic...

  • Probiotics as regulators of inflammation: A review. Lescheid, David W. // Functional Foods in Health & Disease;Jul2014, Vol. 4 Issue 6, p299 

    A substantial and increasing body of clinical evidence supports the role of specific strains and mixtures of probiotics in the prevention and treatment of certain diseases. Several general mechanisms of action have been proposed, including supporting repair of hyperpermeable epithelial barriers,...

  • Relationship between C-reactive protein concentration and cytokine responses to exercise in healthy and illness-prone runners. Cox, Amanda J.; Pyne, David B.; Gleeson, Maree; Callister, Robin // European Journal of Applied Physiology;Nov2009, Vol. 107 Issue 5, p611 

    Differences in the immune and inflammatory response to exercise between healthy and illness-prone athletes may be one explanation why some athletes experience a greater incidence of upper respiratory symptoms than others. The aim of this study was to compare the C-reactive protein (CRP) response...

  • Number of sons contributes to ageing-associated inflammation. Marttila, Saara; Nevalainen, Tapio; Kananen, Laura; Jylhävä, Juulia; Jylhä, Marja; Hervonen, Antti; Ilonen, Jorma; Hurme, Mikko // Scientific Reports;2/27/2015, p8631 

    The rate of inflammation increases in elderly individuals, a phenomenon called inflammaging, and is associated with degenerative diseases. However, the causes of inflammaging and the origin of the associated inflammatory mediators have remained enigmatic. We show herein that there is a positive...

  • BUTYRATE REGULATION OF DISTINCT MACROPHAGE SUBSETS: OPPOSING EFFECTS ON M1 AND M2 MACROPHAGES. Foey, Andrew D. // International Journal of Probiotics & Prebiotics;Aug-Nov2011, Vol. 6 Issue 3/4, p147 

    Mucosal tolerance is central to efficient gastrointestinal tract function, tolerating food and commensal bacteria, whilst maintaining immune responsiveness to pathogens. Mucosal macrophages play a pivotal role in tolerance; whereas in inflammatory bowel disease, dysfunctional macrophages lead to...

  • Is There a Systemic Inflammatory Response in the Acute Charcot Foot? Petrova, Nina L.; Moniz, Caje; Elias, David A.; Buxton-Thomas, Muriel; Bates, Maureen; Edmonds, Michael E. // Diabetes Care;Apr2007, Vol. 30 Issue 4, p997 

    The article focuses on the results of a study regarding the systemic serologic markers of inflammation in acute Charcot osteoarthropathy. It states that there may be correlation between the local inflammatory response seen in patients and the increased expression of proinflammatory cytokines. It...

  • Hypersensitivity vasculitis and cytokines. Nalbant, Selim; Koc, Bayram; Top, Cihan; Kucukardali, Yasar; Baykal, Yavuz; Danaci, Mehmet; Kocer, Ismail Hakki // Rheumatology International;Nov2002, Vol. 22 Issue 6, p244 

    Objective. Hypersensitivity vasculitis (HSV) is secondary vasculitis due to an immune response to exogenous substances. Because of the relative rarity of the vasculitides there are no reports on the role cytokines. This report evaluates some of cytokines which might be involved in...

  • Inflammatory Markers Are Elevated in Eisenmenger Syndrome. Ramakrishnan, Sivasubramanian; Kukreti, Bharat Bhooshan; Ramakrishnan, Lakshmy; Salahuddin, Salman; Pendharkar, Amit; Karthikeyan, Ganesan; Bhargava, Balram; Juneja, Rajnish; Seth, Sandeep; Kothari, Shyam S.; Saxena, Anita; Bahl, Vinay K. // Pediatric Cardiology;Dec2013, Vol. 34 Issue 8, p1791 

    Inflammation may be an important contributing factor to the progression of Eisenmenger syndrome (ES). Markers of systemic inflammation in ES have not been systematically studied. Inflammatory markers including high-sensitivity C-reactive protein (hs-CRP), interleukin-2 (IL-2), IL-6, and...

  • The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older. Jung, Sukyoung; Kim, Mi Kyung; Choi, Bo Youl // PLoS ONE;Jun2015, Vol. 10 Issue 6, p1 

    Background: Serum cytokines and C-reactive protein (CRP) are known as one of the major risk factors in atherosclerosis. The antioxidant and anti-inflammatory properties of zinc have been suggested, but few data are available on the relationship between zinc status and inflammatory markers in...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics