TITLE

Intensity of Intestinal Infection with Multiple Worm Species Is Related to Regulatory Cytokine Output and Immune Hyporesponsiveness

AUTHOR(S)
Turner, Joseph D.; Jackson, Joseph A.; Faulkner, Helen; Behnke, Jerzy; Else, Kathryn J.; Kamgno, Joseph; Boussinesq, Michel; Bradley, Janette E.
PUB. DATE
April 2008
SOURCE
Journal of Infectious Diseases;4/15/2008, Vol. 197 Issue 8, p1204
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Increasing immunological dysfunction (atopy and autoimmunity) in western society may be linked to changes in undetermined environmental agents. We hypothesize that increased exposure to multiple gut worm species promotes stronger immunological regulation. We report here that African children constitutively secrete more immunoregulatory cytokines (interleukin [IL]-10 and transforming growth factor [TGF]- ß1) under conditions of hyperendemic exposure to the intestinal nematodes Ascaris lumbricoides and Trichuris trichiura, compared with conditions of mesoendemic exposure. Under conditions of hyperendemic exposure, estimators of combined intestinal nematode infection level relate positively to combined constitutive IL-10 and TGF-ß1 production and negatively to total immune reactivity (determined as IL-4, interferon-γ, and cellular proliferative responses to Ascaris or Trichuris helminth antigens, Streptococcus pneumoniae bacterial antigen, or the mitogen phytohemaglutinin). Total immune reactivity and anti-inflammatory cytokine production relate inversely. Our data suggest that gut nematodes are important mediators of immunoregulation.
ACCESSION #
31767156

 

Related Articles

  • Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America. Alcântara-Neves, Neuza Maria; Britto, Gabriela de S. G.; Veiga, Rafael Valente; Figueiredo, Camila A.; Fiaccone, Rosimeire Leovigildo; da Conceição, Jackson S.; Cruz, Álvaro Augusto; Rodrigues, Laura Cunha; Cooper, Philip John; Pontes-de-Carvalho, Lain C.; Barreto, Maurício Lima // BMC Research Notes;2014, Vol. 7 Issue 1, p1 

    Background Helminths are modulators of the host immune system, and infections with these parasites have been associated with protection against allergies and autoimmune diseases. The human host is often infected with multiple helminth parasites and most studies to date have investigated the...

  • Ascaris lumbricoides--Induced Interleukin-10 Is Not Associated with Atopy in Schoolchildren in a Rural Area of the Tropics. Cooper, Philip J.; Mitre, Edward; Moncayo, Ana Lucia; Chico, Martha E.; Vaca, Maritza G.; Nutman, Thomas B. // Journal of Infectious Diseases;5/1/2008, Vol. 197 Issue 9, p1333 

    Background. In areas where intestinal helminth infections are endemic, infections by these parasites may protect against skin test-measured reactivity to allergens, and it has been suggested that interleukin (IL)-10 may mediate this effect. This study investigated whether IL-10 and populations...

  • Th2 Cytokines Are Associated with Reduced Worm Burdens in a Human Intestinal Helminth Infection. Turner, Joseph D.; Faulkner, Helen; Kamgno, Joseph; Cormont, Frances; Van Snick, Jacques; Else, Kathryn J.; Grencis, Richard K.; Behnke, Jerzy M.; Boussinesq, Michel; Bradley, Janette E. // Journal of Infectious Diseases;12/1/2003, Vol. 188 Issue 11, p1768 

    Investigates cytokine production in ex vivo whole-blood cultures in response to Ascaris lumbricoides antigen and mitogen in a cross-section of a community where the parasite is hyperendemic. Intensity of A. lumbricoides infection; Levels of cytokines associated with Th2 lymphocytes.

  • A study on the immunological basis of the dissociation between type I-hypersensitivity skin reactions to Blomia tropicalis antigens and serum anti-B. tropicalis IgE antibodies. Ponte, João C. M.; Junqueira, Samuel B.; Veiga, Rafael V.; Barreto, Mauricio L.; Pontes-de-Carvalho, Lain C.; Alcântara-Neves, Neuza M. // BMC Immunology;2011, Vol. 12 Issue 1, p34 

    Background: Two conditions are used as markers of atopy: the presence of circulating anti-allergen IgE antibodies and the presence of positive skin prick test (SPT) reactions to allergenic extracts. The correlation between these conditions is not absolute. This study aimed at investigating...

  • Biliary Calculus of Roundworm Origin. Raney, Robert; Lilly, James; McHardy, Gordon // Annals of Internal Medicine;Mar70, Vol. 72 Issue 3, p405 

    A 12-year-old negro boy with his second episode of jaundice is reported. A stone in the common bile duct contained a cuticle and multiple ova of Ascaris lumbricoides. Characteristics of Ascaris lumbricoides that predispose to formation of biliary stones are discussed. This is the first case of...

  • Ascaris lumbricoides.  // A-Z of Food Safety;2007, p16 

    An encyclopedia entry for "ascaris lumbricoides" is presented. It refers to a large parasitic roundworm sometimes found in the intestines of pigs. Through the eggs consumed by the pigs, this roundworm is transmitted to other pigs, setting up a further infestation in the intestines of those pigs....

  • Nematodes.  // A-Z of Food Safety;2007, p280 

    A definition of the term "nematodes" is presented. It refers to small worms which may infest the organs and systems of food animals, including Ascaris lumbricoides found in the small intestines and bile ducts of pigs, and various types of Strongyli, such as Strongylus micurus, found in the lungs...

  • Human Infection with Ascaris lumbricoides Is Associated with a Polarized Cytokine Response. Cooper, Philip J.; Chico, Martha E.; Sandoval, Carlos; Espinel, Ivan; Guevara, Angel; Kennedy, Malcolm W.; Urban Jr., Joseph F.; Griffin, George E.; Nutman, Thomas B. // Journal of Infectious Diseases;10/1/2000, Vol. 182 Issue 4, p1207 

    Investigates the cytokine and antibody response to adult and larval stages of Ascaris lumbricoides in infected young adults living in an endemic area of Ecuador. Frequencies of peripheral blood mononuclear cells secreting interleukin (IL)-10, interferon-gamma, IL-4 and IL-5 in infected young...

  • Genome sequence puts roundworm on the ropes.  // Australian Life Scientist;10/27/2011, p1 

    The newly-published genome sequence of roundworm is hoped to reveal new targets for diagnosis and treatment of this pervasive pernicious parasite.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics