TITLE

Seasonality of Antibiotic-Resistant Streptococcus pneumoniae That Causes Acute Otitis Media: A Clue for an Antibiotic-Restriction Policy?

AUTHOR(S)
Dagan, Ron; Barkai, Galia; Givon-Lavi, Noga; Sharf, Amir Z.; Vardy, Daniel; Cohen, Ted; Lipsitch, Marc; Greenberg, David
PUB. DATE
April 2008
SOURCE
Journal of Infectious Diseases;4/15/2008, Vol. 197 Issue 8, p1094
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. It is unclear whether reducing antibiotic prescriptions can reduce rates of resistance once resistance becomes prevalent. We attempted to determine whether reduced antibiotic consumption, which is observed yearly in children during the warm season, is associated with a reduction in antibiotic resistance in pneumococcal acute otitis media (AOM). Methods. Antibiotic prescriptions and resistance were measured prospectively during 1999—2003 in 2 demographically distinct populations: Jewish and Bedouin children (aged <5 years) in southern Israel. Associations were assessed using seasonally clustered logistic regression models. Results. The study included 236,466 prescriptions and 3609 pneumococcal isolates. Prescription rates decreased during the warm months by 36% and 15% in Jewish and Bedouin children, respectively (P < .001 for the season). Among Jewish children, higher resistance rates were observed during the cold than the warm months (P < .001 for each antibiotic). This difference remained significant after adjustment for age, ethnic group, study year, history of antibiotic use, and serotype. The difference was not observed in Bedouin children. Conclusions. Rapid seasonal decline in resistant AOM-causing pneumococci occurred only in Jewish children, among whom a marked prescribing seasonality was noted, and not in Bedouin children, among whom prescription was less seasonal. The rapid seasonal decrease in resistance associated with markedly reduced antibiotic use suggests that drug-resistant pneumococci may pay a fitness cost.
ACCESSION #
31767137

 

Related Articles

  • Prevalence, Haemolytic Activities and Flouroquinolones Susceptibility Profiles of Moraxella catarrhalis, Streptococcus pneumoniae and Haemophilus influenzae Associated with Acute Otitis Media. Joseph, Akinjogunla Olajide; Odeh, Eghafona Nosakhare // Nature & Science;Jun2011, Vol. 9 Issue 6, p85 

    This study was designed to determine the prevalence, haemolytic activities and flouroquinolones susceptibility profiles of Moraxella catarrhalis, Streptococcus pneumoniae and Haemophilus influenzae associated with acute otitis media. 272 middle-ear swabbed samples were aseptically collected and...

  • Treatment and outcome of severe and non-severe acute otitis media. Hotomi, Muneki; Yamanaka, Noboru; Samukawa, Takao; Suzumot, Masaki; Sakai, Akihiro; Shimada, Jun; Ikeda, Yorihiko; Faden, Howard // European Journal of Pediatrics;Jan2005, Vol. 164 Issue 1, p3 

    Unlabelled: To determine outcomes in acute otitis media (AOM) according to severity of disease and to assess different initial treatment regimens, 308 with AOM were enrolled and divided into severe (n = 277; 89.9%) and non-severe (n = 31; 10.1%) groups based on symptoms and tympanic...

  • Child vaccine linked to antibiotic-resistant bug. Tanday, Sanjay // GP: General Practitioner;10/19/2007, p2 

    The article discusses a study conducted by researcher Michael Pichichero and colleagues which has found that an antibiotic-resistant strain of Streptococcus pneumoniae is causing problems in the U.S. since introduction of the pneumococcal vaccine. Pichichero said the observations of the study...

  • Literature Reviews: Infectious Diseases. Lampe, John B.; Steele, Russell W.; McDavid, Anthony E. // Clinical Pediatrics;Feb2000, Vol. 39 Issue 2, p127 

    Summary: A group was convened at the CDC to discuss recommendations for the management of acute otitis media (AOM) in light of the increasing prevalence of drug-resistant Streptococcus pneumoniae (DRSP) and to offer recommendations on DRSP surveillance. The group, after surveying both published...

  • Appropriate Treatment of Acute Otitis Media in the Era of Antibiotic Resistance. Dagan, Ron // Pediatric Drugs;2010 Supplement 1, Vol. 12, p3 

    The outcome of treatment for acute otitis media (AOM) differs between various antibiotic drugs. Outcome depends upon the drugs' pharmacokinetics, but in the case of infectious diseases also on the susceptibility of the organism and the interaction between the drug and the organisms at the...

  • Evaluating Children with Otitis Media for Bacteremia or Urinary Tract Infection. Yawman, Daniel; Mahar, Patrick; Blumkin, Aaron; Conners, Gregory // International Journal of Pediatrics;2010, p1 

    Background. It is unclear if clinicians evaluate for concurrent bacteremia or UTI in young patients diagnosed with acute otitis media (AOM). Objectives. To describe how often, and under which circumstances, emergency providers investigate for bacteremia or UTI in 2–36 month olds with AOM....

  • Correlation of nasopharyngeal cultures prior to and at onset of acute otitis media with middle ear fluid cultures. Kaur, Ravinder; Czup, Katerina; Casey, Janet R.; Pichichero, Michael E. // BMC Infectious Diseases;2014, Vol. 14 Issue 1, p118 

    Background We sought to determine if nasopharyngeal (NP) cultures taken at times of healthy visits or at onset of acute otitis media (AOM) could predict the otopathogen mix and antibioticsusceptibility of middle ear isolates as determined by middle ear fluid (MEF) cultures obtained by...

  • Frequency and Resistance Patterns of Streptococcus Pneumoniae in Acute Otitis Media. Soltan Dallal, Mohammad Mehdi; Jabbari, Hossain; Forushani, Abbas Rahimi; Heidarzadeh, Siamak; Afrogh, Parviz; Sharifi Yazdi, Mohammad Kazem // Journal of Mazandaran University of Medical Sciences (JMUMS);Mar2013, Vol. 23 Issue 98, p27 

    Background and purpose: Acute otitis media (AOM) remains a frequent global infection of childhood, with up to 80% of children having at least one episode by three years of age. Ten to 30% have recurrent episodes, and 2-25% will have persistent middle ear effusion extending beyond three months....

  • Nonsevere AOM: Watchful waiting or antibiotics? Burke, Michael G. // Contemporary Pediatrics;Aug2005, Vol. 22 Issue 8, p17 

    This article presents a study on the safety, efficacy, acceptability and cost of watchful waiting and of antibiotics for treating nonsevere acute otitis media (AOM) in children. Patients in the immediate antibiotic treatment group received oral amoxicillin for 10 days at a dosage of 90 mg/kg/day...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics