Premature epiphyseal closure noted in patient taking isotretinoin

Sperling, Mark A.; Southall, Jennifer; Zacharyczuk, Colleen
March 2008
Endocrine Today;3/10/2008, Vol. 6 Issue 4, p7
The article alleges that isotretinoin which is a drug to treat severe acne may be causing premature epiphyseal closure. James Walker, MD, associate professor of dermatology at the University of Ottawa and the Ottawa Hospital, said he noted this condition in a 15-year-old patient for whom he had prescribed the drug. An x-ray showed that his left tibial and fibular growth plates had fused after three months of taking the drug while his growth resumed a year after not taking the medication.


Related Articles

  • Acne 101: An Informational. Jeter Session Derms Should Have With Teens, Darlene // Dermatology Times;Apr98, Vol. 19 Issue 4, p44 

    Assesses some factors necessary in the treatment of acne among teenagers. Medications proposed for all stages of acne treatment; Stress on the dermatologic mechanisms of Isotretinoin treatment; Side effects of Retin-A medication.

  • Isotretinoin.  // Reactions Weekly;2/13/2010, Issue 1288, p25 

    The article describes the case of a 17-year-old boy who developed premature ventricular contractions while undergoing treatment with isotretinoin for nodular facial acne.

  • Long-term safety of isotretinoin reiterated. Guttman, Cheryl // Dermatology Times;Feb96, Vol. 17 Issue 2, p4 

    Reports on a study which reiterated the long-term safety of isotretinoin's treatment of acme. Victoria Goulden's study which reviewed symptoms reported by patients after they discontinued isotretinoin (Accutane); Symptoms and drug link not known.

  • Isotretinoin.  // Reactions Weekly;11/20/2010, Issue 1328, p25 

    The article describes the case of a 16-year-old boy who received treatment with isotretinoin for severe vystic acne, but developed encephalopathy.

  • Isotretinoin dosing alternatives gleaned from experience. Guttman, Cheryl // Dermatology Times;Sep2000 Supplement 4, Vol. 21 Issue 9, pS10 

    Suggests alternatives to manufacturer-recommended dosing schemes for isotretinoin in treating acne. Teratogenic potential of isotretinoin; Guidelines for determining the length of low-dose isotretinoin treatment.

  • Isotretinoin monitoring could be reduced. Guttman, Cheryl // Dermatology Times;Sep2000 Supplement 4, Vol. 21 Issue 9, pS11 

    Suggests that biochemical and hematology laboratory testing of isotretinoin-treated acne patients after two months are not necessary, according to a research. Rare cases of patients developing dangerous blood levels of isotretinoin; Consideration of treatment withdrawal for proposed lipid and...

  • Acne study alerts to suicide risk.  // New Zealand Doctor;12/1/2010, p8 

    The article reports on the results of the retrospective epidemiological study conducted by Swedish researchers, which showed that treatment with the acne drug isotretinoin increases the number of suicide attempts among people with severe acne problem.

  • High-dose isotretinoin reduces risk of acne vulgaris relapse. Talsma, Julia // Formulary;Dec2013, Vol. 48 Issue 12, p1 

    The article discusses a study by Rachel C. Blasiak and her colleagues, published in the periodical "JAMA Dermatology" which found that higher doses of isotretinoin can treat patients with acne vulgaris effectively and reduce the relapse rate without significant increased adverse events. Topics...

  • Severe Facial Hirsutism Following Isotretinoin Therapy: An Under-reported Entity. Ramot, Yuval; Sheffer, Sivan; Zlotogorski, Abraham // International Journal of Trichology;Jul-Sep2015, Vol. 7 Issue 3, p129 

    Hirsutism is usually a manifestation of hyperandrogenism, and iatrogenic causes for excess hair growth are uncommon. Here, we report on a 48-year-old female patient, who developed severe excess facial hair following treatment with isotretinoin for papulopustular rosacea. To the best of our...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics