Ifosfamide neurotoxicity and potential treatment with methylene blue

Lohr, Lisa
April 2008
Hem/Onc Today;4/25/2008, Vol. 9 Issue 7, p15
The article focuses on neurotoxicity as a side effect of ifosfamide, an agent used in cancer treatment, and its potential treatment with methylene blue. Neurotoxicities symptoms reportedly include delirium, confusion, lethargy and disorientation and stated estimates of incidence center around 10 to 20% of patients treated with ifosfamide. Methylene blue it is shown may reduce symptoms and hasten recovery. A proposed dose of 50-mg given intravenously every four hours is noted.


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