Impairment of movement-associated brain deactivation in multiple sclerosis: further evidence for a functional pathology of interhemispheric neuronal inhibition

Manson, S. C.; Wegner, C.; Filippi, M.; Barkhof, F.; Beckmann, C.; Ciccarelli, O.; De Stefano, N.; Enzinger, Christian; Fazekas, F.; Agosta, F.; Gass, A.; Hirsch, J.; Johansen-Berg, H.; Kappos, L.; Korteweg, T.; Polman, C.; Mancini, L.; Manfredonia, F.; Marino, S.; Miller, D. H.
May 2008
Experimental Brain Research;May2008, Vol. 187 Issue 1, p25
Academic Journal
Motor control demands coordinated excitation and inhibition across distributed brain neuronal networks. Recent work has suggested that multiple sclerosis (MS) may be associated with impairments of neuronal inhibition as part of more general progressive impairments of connectivity. Here, we report results from a prospective, multi-centre fMRI study designed to characterise the changes in patients relative to healthy controls during a simple cued hand movement task. This study was conducted at eight European sites using 1.5 Tesla scanners. Brain deactivation during right hand movement was assessed in 56 right-handed patients with relapsing-remitting or secondary progressive MS without clinically evident hand impairment and in 60 age-matched, healthy subjects. The MS patients showed reduced task-associated deactivation relative to healthy controls in the pre- and postcentral gyri of the ipsilateral hemisphere in the region functionally specialised for hand movement control. We hypothesise that this impairment of deactivation is related to deficits of transcallosal connectivity and GABAergic neurotransmission occurring with the progression of pathology in the MS patients. This study has substantially extended previous observations with a well-powered, multicentre study. The clinical significance of these deactivation changes is still uncertain, but the functional anatomy of the affected region suggests that they could contribute to impairments of motor control.


Related Articles

  • An unusual variant of the dorsal midbrain syndrome in MS: clinical characteristics and pathophysiologic mechanisms. Frohman, Elliot M; DeweY, Richard B; Frohman, Teresa C // Multiple Sclerosis (13524585);Jun2004, Vol. 10 Issue 3, p322 

    Patients with MS exhibit a broad diversity of ocular motor syndromes. We describe a patient with relapsing-remitting MS who developed an unusual variation of the dorsal midbrain syndrome, characterized by monocular convergent-retraction nystagmus in the right eye, accompanied by...

  • Cortical deficits in multiple sclerosis on the basis of subcortical lesions. Jeffery, D.R.; Absher, J.; Pfeiffer, F.E.; Jackson, H. // Multiple Sclerosis (13524585);Feb2000, Vol. 6 Issue 1, p50 

    Patients suffering from multiple sclerosis have a high frequency of cognitive deficits usually attributable to demyelination and axonal loss in the subcortical white matter. Neurologic abnormalities referable to cortical function are uncommon but have been described. The present study describes...

  • Hypothalamic stimulation for trigeminal neuralgia in multiple sclerosis patients: efficacy on the paroxysmal ophthalmic pain. Cordella, R.; Franzini, A.; La Mantia, L.; Marras, C.; Erbetta, A.; Broggi, G. // Multiple Sclerosis (13524585);Nov2009, Vol. 15 Issue 11, p1322 

    Trigeminal neuralgia is a disorder characterized by paroxysmal pain arising in one or more trigeminal branches; it is commonly reported in multiple sclerosis. In multiple sclerosis patients the ophthalmic branch may be frequently involved and the risks carried by neurosurgical ablative...

  • Heart Rate Variability in Patients With Multiple Sclerosis. Bektaşsli, Fevzi; Yildiz, Özlem Kayim; Segmen, Hatice; Bolayir, Ertuğrul; Toapktaş, Suat // Journal of Neurological Sciences;2009, Vol. 26 Issue 3, p271 

    Objective: The aims of the present study were to compare heart rate variability (HRV) parameters of patients with multiple sclerosis (MS) and healthy controls and to investigate the correlations between HRV parameters and disease duration, subtype and severity. Methods: Thirty-two patients with...

  • More data on exercise for fatigue.  // Inside MS;Oct-Dec2003, Vol. 21 Issue 4, p38 

    Reports on a study conducted by researchers in Portland, Oregon regarding the effects of exercise on levels of fatigue in people with multiple sclerosis. Highlights of the study; Results of the experiments conducted.

  • Multiple symmetric lipomatosis (MSL) of neck in a child (Madelung's disease): report of a rare presentation. Shetty, C.; Avinash, K. R.; Auluck, A.; Mupparapu, M. // Dentomaxillofacial Radiology;Jan2007, Vol. 36 Issue 1, p51 

    A case of multiple symmetric lipomatosis (MSL) of neck, also known as Madelung's disease or Launois-Bensaude syndrome, is reported in an 8-year-old girl who presented with bilateral swellings in the neck. MSL is characterized by large subcutaneous fat masses distributed around the neck,...

  • The effects of anxiety on psychiatric morbidity in patients with multiple sclerosis. Feinstein, A.; O'Connor, P.; Gray, T.; Feinstein, K. // Multiple Sclerosis (13524585);Oct99, Vol. 5 Issue 5, p323 

    Our objective was to assess the point prevalence and effects of clinically significant anxiety in patients with Multiple Sclerosis (MS). One hundred and fifty two consecutive patients with MS attending an outpatient clinic underwent neurological examination and were assessed for psychopathology...

  • Subthalamic nucleus stimulation reverses spinal motoneuron activity in parkinsonian patients. Raoul, Sylvie; Roualdes, Vincent; Deligny, Céline; Leduc, Dominique; Lamy, Jean-Charles; Lackmy-Vallée, Alexandra; N'Guyen, Jean-Paul; Damier, Philippe; Katz, Rose // Brain: A Journal of Neurology;Jan2012, Vol. 135 Issue 1, p139 

    Although a cardinal symptom of Parkinsonian disease, up to now, rigidity has been investigated much less than spasticity in hemiplegic patients. Many pathophysiological mechanisms may at least theoretically contribute to Parkinsonian rigidity, from altered viscoelastic muscle properties to...

  • Is central fatigue in multiple sclerosis a disorder of movement preparation? Morgante, Francesca; Dattola, Vincenzo; Crupi, Domenica; Russo, Margherita; Rizzo, Vincenzo; Ghilardi, Maria Felice; Terranova, Carmen; Girlanda, Paolo; Quartarone, Angelo // Journal of Neurology;Feb2011, Vol. 258 Issue 2, p263 

    We tested the hypothesis that fatigue in MS is related to a dysfunction in cortical areas involved in movement preparation. Thirty-three patients with clinically definite MS (16 with fatigue MS-F, 17 without fatigue MS-NF) and a relapsing-remitting course, matched for disease severity and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics