Impact of amblyopia on vision at age 12 years: findings from a population-based study

Robaei, D.; Kifley, A.; Rose, K. A.; Mitchell, P.
April 2008
Eye;Apr2008, Vol. 22 Issue 4, p496
Academic Journal
AimsTo report prevalence of amblyopia and long-term impact of its treatment on vision in a population-based sample of 12-year-old Australian children.MethodsLogarithm of minimum angle of resolution (logMAR) visual acuity (VA) was measured in 2353 children (response rate 75.3%); visual impairment was defined as VA<6/12. Amblyopia was defined using various criteria of best-corrected VA, together with an amblyogenic factor and absence of significant organic pathology. Corroborative historical data on previous diagnosis and treatment were obtained from parental questionnaires.ResultsForty-four children (1.9%) were diagnosed with amblyopia, unilateral in 40 and bilateral in four. Isolated anisometropia was the most frequent cause (41%), followed by strabismus (25%), combined anisometropia and strabismus (23%), and high ametropia (9%). Myopia, hyperopia, and astigmatism were present in 28, 51, and 44% of amblyopic children, respectively, compared to 12, 4, and 9% of non-amblyopic children. Mean best-corrected VA in amblyopic eyes was 44.5 logMAR letters (Snellen equivalent 6/9), range: 11–60 letters. Most children with amblyopia (84%) had been treated. Only 27% were visually impaired in their amblyopic eye.ConclusionsThis report documents a low amblyopia prevalence in a population of 12-year-old Australian children. Amblyopic visual impairment was infrequent in this sample despite absence of mandatory vision screening.Eye (2008) 22, 496–502; doi:10.1038/sj.eye.6702668; published online 23 March 2007


Related Articles

  • Evaluation of central, steady, maintained fixation grading for predicting inter-eye visual acuity difference to diagnose and treat amblyopia in strabismic patients. Kothari, Mihir; Bhaskare, Amar; Mete, Deepali; Toshniwal, Svetlana; Doshi, Priti; Kaul, Shalini // Indian Journal of Ophthalmology;Sep2009, Vol. 57 Issue 4, p281 

    Background: Diagnosis of amblyopia in preverbal strabismic patients is frequently made by binocular fixation preference (BFP) testing. The reports on reliability of BFP are equivocal. This study evaluated the reliability of BFP testing in patients with horizontal strabismus. Materials and...

  • Effect of oral CDP-choline on visual function in young amblyopic patients. Michela Fresina; Anna Dickmann; Annabella Salerni; Fabio De Gregorio; Emilio Campos // Graefe's Archive of Clinical & Experimental Ophthalmology;Jan2008, Vol. 246 Issue 1, p143 

    Abstract Purpose  The purpose of the study was to evaluate the effect on visual function of orally administered CDP-choline in addition to patching for the treatment of amblyopia in children. Methods  This was an open label parallel group study comparing...

  • Predicting potential acuities in amblyopes. William Ridder; Michael Rouse // Documenta Ophthalmologica;May2007, Vol. 114 Issue 3, p135 

    Abstract Purpose  Amblyopic patients, or their parents, often want to know the potential for success before committing to treatment. Recent reports have indicated that the pattern visual evoked potential (pVEP) can be used as a predictor of the success of amblyopia therapy....

  • Phenotypical characteristics of idiopathic infantile nystagmus with and without mutations in FRMD7. Shery Thomas; Frank A. Proudlock; Nagini Sarvananthan; Eryl O. Roberts; Musarat Awan; Rebecca McLean; Mylvaganam Surendran; A. S. Anil Kumar; Shegufta J. Farooq; Chris Degg; Richard P. Gale; Robert D. Reinecke; Geoffrey Woodruff; Andrea Langmann; Susanne Lindner; Sunila Jain; Patrick Tarpey; F. Lucy Raymond; Irene Gottlob // Brain: A Journal of Neurology;May2008, Vol. 131 Issue 5, p1259 

    Idiopathic infantile nystagmus (IIN) consists of involuntary oscillations of the eyes. The familial form is most commonly X-linked. We recently found mutations in a novel gene FRMD7 (Xq26.2), which provided an opportunity to investigate a genetically defined and homogeneous group of patients...

  • Comparação do teste modificado de fixação preferencial com o convencional em pacientes com estrabismo. PROCIANOY, EDSON; PROCIANOY, LETÍCIA // Arquivos Brasileiros de Oftalmologia;2012, Vol. 75 Issue 2, p87 

    Purpose: To compare the accuracy of the fixation preference test performed with the patient touching and looking at the fixation target, to the conventional method test done with the patient only looking at it. Methods: A pilot transversal and prospective study was done with 40 strabismic...

  • Current Concepts of Amblyopia: A Neuro-Ophthalmology Perspective. Roper-Hall, Gill // American Orthoptic Journal;2007, Vol. 57, p2 

    Amblyopia can be defined as a developmental disorder in which there is a deficit in visual acuity that cannot be improved by refractive correction and that has no detectable organic cause. It has been recognized as a clinical entity for over 300 years. Amblyopia can no longer be considered a...

  • Part-time vs. Full-time Occlusion for Amblyopia: Evidence for Part-time Patching. Matta, Noelle S.; Silbert, David I. // American Orthoptic Journal;2013, Vol. 63, p14 

    Amblyopia is characterized by a decreased uncorrectable visual acuity in a structurally normal eye. Occlusion therapy has been used for years to improve acuity, and, traditionally, practitioners have utilized full-time patching. This article will explore more recent research looking at using...

  • Controversy in Amblyopia Management. Walsh, Leah A.; Hahn, Erik K.; LaRoche, G. Robert // American Orthoptic Journal;2006, Vol. 56, p116 

    Background and Purpose: Much has been written about amblyopia treatment. However, there is no consensus on the most efficacious therapeutic modality for amblyopia. The intensity of therapy needed to maximize visual acuity is also widely debated. The diversity of opinions emphasizes that the...

  • Contrast gain control and cortical TrkB signaling shape visual acuity. Heimel, J. Alexander; Saiepour, M. Hadi; Chakravarthy, Sridhara; Hermans, Josephine M.; Levelt, Christiaan N. // Nature Neuroscience;May2010, Vol. 13 Issue 5, p642 

    During development and aging and in amblyopia, visual acuity is far below the limitations set by the retina. Expression of brain-derived neurotrophic factor (BDNF) in the visual cortex is reduced in these situations. We asked whether neurotrophic tyrosine kinase receptor, type 2 (TrkB) regulates...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics