Preconditioning with death ligands FasL and TNF-Î± protects the cirrhotic mouse liver against ischaemic injury
- Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNFa gene. Smith, Robert M.; Suleman, Naushaad; McCarthy, Joy; Sack, Michael N. // Cardiovascular Research;Aug2002, Vol. 55 Issue 3, p553
Objective: Tumor necrosis factor alpha (TNFa) is known to mimic ischemic preconditioning (IP). However, it is not known whether TNFa-preconditioning is mediated by ï¿½establishedï¿½ preconditioning signaling or via novel signaling cascades. Moreover, whether TNFa is required to...
- OX40:OX40L Axis: Emerging Targets for Immunotherapy of Human Disease. Salek-Ardakani, Shahram; Song, Aihua; Humphreys, Ian R.; Croft, Michael // Current Immunology Reviews;2006, Vol. 2 Issue 1, p37
Recent advances in our understanding of the mechanisms through which T cells are activated have led to new therapeutic approaches in the treatment of immunological disorders. An emerging target for selective immune intervention has been the manipulation of T cell costimulatory pathways....
- Intratracheal instillation versus intratracheal inhalation:... Osier, M.; Baggs, R.B.; Oberdorster, G. // Environmental Health Perspectives Supplements;Sep97 Supplement 5, Vol. 105, p1265
Studies the roles that macrophage inflammatory protein-2 (MIP-2) and tumor necrosis factor alpha (TNF-alpha) may play in the observed differences in bronchoalveolar lavage (BAL) parameters. Methodology used; Analysis of the results; Conclusions.
- Burning up TNF toxicity for cancer therapy. Leist, Marcel; Jäättelä, Marja // Nature Medicine;Jul2002, Vol. 8 Issue 7, p667
Cites a study that shows that tumor necrosis factor (TNF) loses its toxicity but still kills tumors in heat treated mice. Association between the tumor killing capacity and the systemic toxicity of the cytokine TNF; Failure of heat treatment to protect against TNF induced lethality in mice.
- Tumor Necrosis Factor (TNF). Vohr, Hans-Werner // Encyclopedic Reference of Immunotoxicology;2005, p674
The article presents an encyclopedia definition for tumor necrosis factor (TNF). The TNF-Î± and TNF-Î² lymphotoxin are types of TNF produced by macrophages and T lymphocytes. It was first described as cytotoxins for tumor cells. It is also known as cachectin.
- Cunning factor: macrophage migration inhibitory factor as a redox-regulated target. Kudrin, Alex; Ray, David // Immunology & Cell Biology;Apr2008, Vol. 86 Issue 3, p232
Macrophage migration inhibitory factor (MIF) has an amazing history of rediscoveries and controversies surroundings its true biological function. It has been classified as a powerful cytokine capable of inducing tumour necrosis factor (TNF)-Î±, IL-1Î², IL-6, IL-8, PGE2 along with its ability...
- Effect of soluble interleukin-6 receptor a and interleukin-6 secreted by polymorphonuclear leukocytes on tumor necrosis factor-a expression and its production by peripheral blood mononuclear cells. Jablonska, E. // Mediators of Inflammation;Oct2002, Vol. 11 Issue 5, p325
Background: It has recently been shown that soluble interleukin-6 receptor (sIL-6R) alone or complexed with interleukin (IL)-6, besides their regulatory role in a wide variety of both normal and abnormal biologic reactions mediated by IL-6, could be an effective stimulator of the cell function....
- Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria. Schofield, Louis; Hewitt, Michael C.; Evans, Krystal; Siomos, Mary-Anne; Seeberger, Peter H. // Nature;8/15/2002, Vol. 418 Issue 6899, p785
Examines whether anti-glycosylphosphatidylinositol (GPI) vaccination could prevent pathology and fatalities in the Plasmodium berghei/rodent model of severe malaria. Use of tumor-necrosis factor-alpha production of macrophages as a biochemical marker of malarial endotoxin activity in vitro;...
- Cytokine-induced macrophage differentiation: a tale of 2 genes. Winston, Brent W.; Krein, Peter M. // Clinical & Investigative Medicine;Dec99, Vol. 22 Issue 6, p236
Macrophages are versatile cells found in every tissue in the body. They must perform a number of diverse cellular functions that allow them to kill invading microorganisms and neoplastic cells as well as produce growth factors involved in wound healing. Macrophages that develop these diverse...