Mast cells and cellularity of the colonic mucosa correlated with fatigue and depression in irritable bowel syndrome

Piche, T.; Saint-Paul, M. C.; Dainese, A.; Marine-Barjoan, E.; Iannelli, A.; Montoya, M. L.; Peyron, J. F.; Czerucka, D.; Cherikh, F.; Filippi, J.; Iran, A.; Hébuterne, X.
April 2008
Gut;Apr2008, Vol. 57 Issue 4, p468
Academic Journal
Background: A subset of patients with irritable bowel syndrome (IBS) have an increased number of mast cells (MCs) in the colonic mucosa. Psychological factors are believed to contribute to the course of lBS. Aims: To examine associations between fatigue, depression and MCs of the colonic mucosa in lBS. Methods: Colonic biopsies were taken from 50 Rome II lBS patients, 21 healthy controls and 11 depressed! fatigued patients without lBS. The cellularity of the lamina propria was determined as the number of inflammatory cells per high power field (hpf) through a 400 × microscope. The Fatigue Impact Scale (FIS) and the short form Beck Depression Inventory (801) evaluated the severity of fatigue and depression. Results: lBS patients had a significant increase in the cellularity of the lamina propria compared with controls or with depressed patients (mean (SD) 94.5 (48-110) vs 68 (58-82) and 78(87-90) cells per hpf, p = 0.005 and p = 0.05, respectively), in particular of MCs (9.3 (5.6-11.7) vs 4.0 (2.7-6.8) and 4.3 (2.8-7.8) cells per hpf, p = 0.001 and p = 0.005, respectively). Both the FIS and BDI scores were significantly higher in lBS or in depressed patients than in controls (p<0.001). In lBS. the FIS score correlated significantly with the cellularity of the lamina propria )r= 0.51, p<0.0001) and MCs (r= 0.64, p<0.0001). In IBS, the BDI score correlated significantly with MCs (r = 0.29, p = 0.03). Conclusions: Elevated MCs counts are a key feature of the low-grade inflammatory infiltrate in the caecal mucosa of lBS. Fatigue and depression are associated with mucosal cell counts, in particular MCs, suggesting that psychological factors are associated with the low-grade inflammatory infiltrate in lBS.


Related Articles

  • Mucosal Mast Cell Count Is Associated With Intestinal Permeability in Patients With Diarrhea Predominant Irritable Bowel Syndrome. Hyuk Lee; Jung Ho Park; Dong Il Park; Hong Joo Kim; Yong Kyun Cho; Chong Il Sohn; Woo Kyu Jeon; Byung Ik Kim; Seoung Wan Chae // Journal of Neurogastroenterology & Motility;Apr2013, Vol. 19 Issue 2, p244 

    Background/Aims: Although mucosal mast cell tryptase is known to significantly increase intestinal permeability, the relationship between mucosal mast cells and intestinal permeability remains unclear. The objective of this study was to evaluate the correlation among intestinal permeability,...

  • Effect of the pollen season on nasal mast cells. Viegas, M.; Gomez, E.; Brooks, J.; Gatland, D.; Davies, R.J. // British Medical Journal (Clinical Research Edition);2/14/1987, Vol. 294 Issue 6569, p414 

    Examines the effect of the pollen season on the total number of mast cells in the nasal mucous membrane. Concept of the phenomenon nasal priming; Increase in the superficial epithelial cell layer; Migration of mast cells to the nasal epithelium.

  • Irritable Bowel Syndrome Patients Versus Responding and Nonresponding Temporomandibular Disorder Patients: A Neuropsychologic Profile Comparative Study. Grossi, Márcio L.; Goldberg, Michael B.; Locker, David; Tenenbaum, Howard C. // International Journal of Prosthodontics;2008, Vol. 21 Issue 3, p201 

    Purpose: This study aimed to assess the use of neuropsychologic tests as a tool to differentiate, or not, between a nonresponding chronic pain condition of nonmuscular origin, irritable bowel syndrome (IBS) (n = 20), versus 2 pain conditions of muscular origin, responding (n = 36) and...

  • Regulatory Mechanism of Electroacupuncture in Irritable Bowel Syndrome: Preventing MC Activation and Decreasing SP VIP Secretion. Huan-Gan Wu; Bin Jiang; En-Hua Zhou; Zheng Shi; Da-Ren Shi; Yun-Hua Cui; Suo-Tang Kou; Hui-Rong Liu // Digestive Diseases & Sciences;Jun2008, Vol. 53 Issue 6, p1644 

    Abstract  The efficacy of electroacupuncture (EA) for treating patients with diarrhea-predominant IBS has been confirmed in the authors’ former research, but the regulatory mechanism of EA in IBS is still unknown. The aim of this study was to explore the relationship between the...

  • The Radiology Corner∗. Berk, Robert N.; Werner, Leslie G. // American Journal of Gastroenterology;Feb1974, Vol. 61 Issue 2, p145 

    Presents case studies on the radiologic features of colonic lipomas in patients. Percentage of colonic lipomas that are submucosal in origin and are covered with intact mucosa; Factors which suggest the presence of a lipoma; Recommended treatment for uncomplicated colonic lipomas.

  • Migraine, fibromyalgia, and depression among people with IBS: a prevalence study. Cole, J. Alexander; Rothman, Kenneth J.; Cabral, Howard J.; Yuqing Zhang; Farraye, Francis A. // BMC Gastroenterology;2006, Vol. 6, p26 

    Background: Case descriptions suggest IBS patients are more likely to have other disorders, including migraine, fibromyalgia, and depression. We sought to examine the prevalence of these conditions in cohorts of people with and without IBS. Methods: The source of data was a large U.S. health...

  • Effects of NB001 and gabapentin on irritable bowel syndrome-induced behavioral anxiety and spontaneous pain. Ming-Ming Zhang; Shui-Bing Liu; Tao Chen; Kohei Koga; Ting Zhang; Yun-Qing Li; Min Zhuo // Molecular Brain;2014, Vol. 7 Issue 1, p2 

    Irritable bowel syndrome (IBS) is characterized by recurrent abdominal discomfort, spontaneous pain, colorectal hypersensitivity and bowel dysfunction. Patients with IBS also suffer from emotional anxiety and depression. However, few animal studies have investigated IBS-induced spontaneous pain...

  • Quantitative analysis of mast cells in oral submucous fibrosis. Chavan, Surekha; Deshmukh, R. S. // Al Ameen Journal of Medical Sciences;Apr-Jun2013, Vol. 6 Issue 2, p144 

    Back ground: On the Indian subcontinent, the use of smokeless tobacco in various forms is very popular. Oral submucous fibrosis is a chronic condition of the oral mucosa, which results in a marked rigidity with progressive inability to open the mouth and has an increased risk of undergoing...

  • Mast Cell Density in Cardio-Esophageal Mucosa. Mahjoub, Fatemeh E.; Asefi, Hoda; Farahmand, Fatemeh; Pourpak, Zahra; Abbasi, Ata; Amini, Zahra // Iranian Journal of Allergy, Asthma & Immunology;Dec2014, Vol. 13 Issue 6, p447 

    Mast cells are related to certain gastrointestinal complaints. Mast cell density has not been studied in cardio-esophageal region to the best of our knowledge. In this study we wanted to obtain an estimate of mast cell density in this region and compare it with mast cell density in antrum. From...


Read the Article


Sign out of this library

Other Topics