Process steps and suggestions for creating drug monographs and drug class reviews in an evidence-based formulary system

Strite, Sheri A.; Stuart, Michael E.; Urban, Shaun
April 2008
Formulary;Apr2008, Vol. 43 Issue 4, p135
Academic Journal
Given the high estimates of inappropriate healthcare decisions in this country and the well-documented evidence of inappropriate variations in healthcare, a well-functioning formulary system is of great importance. Bias in research tends to inflate or falsely report benefit in clinical trials of interventions by up to a relative 40% to 50%. Therefore, to ensure the adoption of products with valid and clinically useful outcomes, formulary systems should include in their processes the key steps used in evidence-based medicine, including the evaluation of therapeutic studies for bias and clinical usefulness to inform formulary decisions. This article outlines requirements and suggestions for obtaining studies with appropriate designs and acceptable methodology and execution, and emphasizes why such studies should be the basis for developing drug monographs and class reviews and informing decisions.


Related Articles

  • How we can contribute to clinical research. Boothe, Dawn Merton // Veterinary Medicine;Sep2008, Vol. 103 Issue 9, p482 

    The article focuses on the importance of clinical trials. It mentions that clinical trials constitute the foundation of evidence-based medicine. Moreover, it strengthens recruitment and retention of clinical faculty. Although there are challenges such as financial constraints and complicated...

  • Your turn to learn to read: Evaluating articles about treatment in the medical literature. Christakis, Dimitri A. // Contemporary Pediatrics;May2003, Vol. 20 Issue 5, p79 

    Discusses a comprehensive way of evaluating any published study that addresses a treatment for a disease or condition in order to help physicians who practice evidence-based medicine apply the findings to the care of patients. Benefits of considering a research that used the randomized method...

  • Is Evidence-Based Medicine Relevant to the Developing World? Chinnock, Paul; Siegfried, Nandi; Clarke, Mike // PLoS Medicine;May2005, Vol. 2 Issue 5, p367 

    Examines the relevance of evidence-based medicine in the developing world. Limitations of the relevance of systematic reviews to frontline health care workers in developing countries; Difficulties of conducting randomized controlled trials in resource-poor situations; Lack of research in...

  • The best treatment? It's at your fingertips. Lowes, Robert // Medical Economics;3/4/2005, Vol. 82 Issue 5, pTCP15 

    Reports on how web sites about evidence-based medicine can help physicians treat individual patients in light of the best available research. Capability of these web sites to rate research according to the level of evidence it offers; List of web sites that offers researches on evidence-based...

  • Evidence-Based Medicine Case Studies.  // Health Affairs;Jan/Feb2005, Vol. 24 Issue 1, p41 

    This article focuses on evidence-based medicine. Clinical trials for evidence-based medicine (EBM) can stop traditional therapies dead in their tracks; likewise, they can introduce new drugs and procedures to medical practice. Findings from previous studies have spurred the EBM community to...

  • Evaluating Evidence.  // Health Affairs;Jan/Feb2005, Vol. 24 Issue 1, p79 

    This article focuses on the concept of evidence-based medicine (EBM). Notwithstanding the epidemic of hype that surrounds and obscures the concept of EBM, increased efforts to systematically collect and disseminate clinical research results to practitioners are a necessary and appropriate...

  • When Is Evidence Sufficient? Claxton, Karl; Cohen, Joshua T.; Neumann, Peter J. // Health Affairs;Jan/Feb2005, Vol. 24 Issue 1, p93 

    Traditional conceptualizations of evidence-based medicine rely heavily on randomized controlled trials. Although initiatives to broaden definitions of evidence have been advanced, they generally have not tied evidentiary criteria formally and quantitatively to the benefits and costs involved in...

  • Implementing Evidence.  // Health Affairs;Jan/Feb2005, Vol. 24 Issue 1, p137 

    This article focuses on evidence-based research in the field of medicine. No medical research helps patients if clinicians do not adopt practices supported by evidence. As Carolyn Clancy, director of the Agency for Healthcare Research and Quality, says that research has undergone explosive...

  • Evidence-Based Quality Improvement: The State Of The Science. Shojania, Kaveh G.; Grimshaw, Jeremy M. // Health Affairs;Jan/Feb2005, Vol. 24 Issue 1, p138 

    Routine practice fails to incorporate research evidence in a timely and reliable fashion. Many quality improvement (QI) efforts aim to close these gaps between clinical research and practice. However, in sharp contrast to the paradigm of evidence-based medicine, these efforts often proceed on...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics