TITLE

Characteristics of Ossified Lesions in the Upper Cervical Spine Associated with Ossification of the Posterior Longitudinal Ligament in the Lower Cervical Spine

AUTHOR(S)
Kawaguchi, Yoshiharu; Seki, Shoji; Hori, Takeshi; Kimura, Tomoatsu
PUB. DATE
April 2008
SOURCE
Journal of Bone & Joint Surgery, American Volume;Apr2008, Vol. 90-A Issue 4, p748
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Ossified lesions of the upper cervical spine behind the dens may cause cervical myelopathy. We investigated the prevalence of ossified lesions in patients with ossification of the posterior longitudinal ligament in order to clarify the characteristics of these patients. Methods: Fifty-six consecutive patients with ossification of the posterior longitudinal ligament in the cervical spine were included in the study. Multidetector computed tomography images of the whole spine were made. Ossified lesions of the upper cervical spine were defined as ossified lesions behind the dens as seen on axial computed tomography images. The prevalence of ossified lesions at the first cervical level was analyzed. The clinical and radiographic parameters were compared between the patients with ossified lesions at the first cervical level and the patients without such lesions. Results: Fourteen patients (25%) had ossified lesions of the upper cervical spine. The continuous type of ossification of the posterior longitudinal ligament in the lower cervical spine was common and the segmental type was rare in this group as compared with the types of ossification in the group without ossified lesions at the first cervical level. The patients with first cervical level ossification more frequently had ossification of the posterior longitudinal ligament in the thoracic and/or lumbar spine, compared with the patients without upper cervical ossification. One patient had cervical myelopathy as a result of the upper cervical ossified lesion. Conclusions: Computed tomography imaging demonstrated the presence of ossified lesions behind the dens in 25% of patients with subaxial ossification of the posterior longitudinal ligament. These upper cervical ossified lesions were commonly seen in patients with multiple-level ossification of the posterior longitudinal ligament. When upper cervical ossified lesions cause severe narrowing of the spinal canal, they should be considered a potential cause of cervical myelopathy. Level of Evidence: Diagnostic Level IV. See Instructions to Authors for a complete description of levels of evidence.
ACCESSION #
31599976

 

Related Articles

  • SMA CARNI-VAL Trial Part I: Double-Blind, Randomized, Placebo-Controlled Trial of L-Carnitine and Valproic Acid in Spinal Muscular Atrophy. Swoboda, Kathryn J.; Scott, Charles B.; Crawford, Thomas O.; Simard, Louise R.; Reyna, Sandra P.; Krosschell, Kristin J.; Acsadi, Gyula; Elsheik, Bakri; Schroth, Mary K.; D'Anjou, Guy; LaSalle, Bernard; Prior, Thomas W.; Sorenson, Susan L.; Maczulski, Jo Anne; Bromberg, Mark B.; Chan, Gary M.; Kissel, John T. // PLoS Clinical Trials;Aug2010, Vol. 7 Issue 8, Special section p1 

    Background: Valproic acid (VPA) has demonstrated potential as a therapeutic candidate for spinal muscular atrophy (SMA) in vitro and in vivo. Methods: Two cohorts of subjects were enrolled in the SMA CARNIVAL TRIAL, a non-ambulatory group of "sitters" (cohort 1) and an ambulatory group of...

  • Unilateral laminoplasty with lateral mass screw fixation for less invasive decompression of the cervical spine: a biomechanical investigation. Schmeiser, Gregor; Schilling, C.; Grupp, T.; Papavero, L.; Püschel, K.; Kothe, R.; Grupp, T M; Püschel, K // European Spine Journal;Dec2015, Vol. 24 Issue 12, p2781 

    Purpose: To compare the stabilization behavior of additional unilateral mass screw fixation with current standard procedures in patients with cervical spondylotic myelopathy (CSM) in a biomechanical study.Methods: Ten human C2-C7 cervical specimens were tested under...

  • Towards the control of a powered orthosis for people with muscular dystrophy. Rahman, T; Ramanathan, R; Stroud, S; Sample, W; Seliktar, R; Harwin, W; Alexander, M; Scavina, M // Proceedings of the Institution of Mechanical Engineers -- Part H;May2001, Vol. 215 Issue 3, p267 

    The paper describes the development of a passive/active orthosis for people with limited anti-gravity strength in their arms. This is symptomatic of conditions such as muscular dystrophy and spinal muscular atrophy. A passive orthosis was designed and developed using linear elastic elements. The...

  • Proximal spinal muscular atrophy: current orthopedic perspective. Haaker, Gerrit; Fujak, Albert // Application of Clinical Genetics;2013, Vol. 6, p113 

    Spinal muscular atrophy (SMA) is a hereditary neuromuscular disease of lower motor neurons that is caused by a defective "survival motor neuron" (SMN) protein that is mainly associated with proximal progressive muscle weakness and atrophy. Although SMA involves a wide range of disease severity...

  • Is Intraoperative CT of Posterior Cervical Spine Instrumentation Cost-effective and Does It Reduce Complications? Hecht, Andrew C.; Koehler, Steven M.; Laudone, Janelle C.; Jenkins, Arthur; Qureshi, Sheeraz // Clinical Orthopaedics & Related Research;Apr2011, Vol. 469 Issue 4, p1035 

    Background: Symptomatic multilevel cervical myelopathy is often addressed using posterior decompression using two-dimensional fluoroscopy. Intraoperative three-dimensional fluoroscopy provides more accurate information on the position of instrumentation to prevent screw-related complications....

  • Feasibility of isometric spinal muscle training in patients with bone metastases under radiation therapy - first results of a randomized pilot trial. Rief, Harald; Omlor, Georg; Akbar, Michael; Welzel, Thomas; Bruckner, Thomas; Rieken, Stefan; Haefner, Matthias F.; Schlampp, Ingmar; Gioules, Alexandros; Habermehl, Daniel; von Nettelbladt, Friedbert; Debus, Jürgen // BMC Cancer;2014, Vol. 14 Issue 1, p1 

    Background Spinal bone metastases are commonly diagnosed in cancer patients. The consequences are pain both at rest and under exercise, impairment of activities of daily life (ADL), reduced clinical performance, the risk of pathological fractures, and neurological deficits. The aim of this...

  • SMA CARNI-VAL Trial Part I: Double-Blind, Randomized, Placebo-Controlled Trial of L-Carnitine and Valproic Acid in Spinal Muscular Atrophy. Swoboda, Kathryn J.; Scott, Charles B.; Crawford, Thomas O.; Simard, Louise R.; Reyna, Sandra P.; Krosschell, Kristin J.; Acsadi, Gyula; Elsheik, Bakri; Schroth, Mary K.; D'Anjou, Guy; LaSalle, Bernard; Prior, Thomas W.; Sorenson, Susan L.; Maczulski, Jo Anne; Bromberg, Mark B.; Chan, Gary M.; Kissel, John T. // PLoS ONE;2010, Vol. 5 Issue 8, p1 

    Background: Valproic acid (VPA) has demonstrated potential as a therapeutic candidate for spinal muscular atrophy (SMA) in vitro and in vivo. Methods: Two cohorts of subjects were enrolled in the SMA CARNIVAL TRIAL, a non-ambulatory group of ''sitters'' (cohort 1) and an ambulatory group of...

  • Myelopathy Caused by Chronic Epidural Hematoma Associated with L1 Osteoporotic Vertebral Collapse: A Case Report and Review of the Literature. Oda, Itaru; Fujiya, Masanori; Hasegawa, Kyoichi; Terae, Satoshi // Open Orthopaedics Journal;2008, Vol. 2, p40 

    Epidural hematoma associated with osteoporotic vertebral collapse has not been reported yet in the literature. We report a case of myelopathy caused by chronic epidural hematoma associated with L1 osteoporotic vertebral collapse and review the relevant literature.

  • Fractures in proximal spinal muscular atrophy. Fujak, Albert; Kopschina, Carsten; Forst, Raimund; Gras, Florian; Mueller, Lutz Arne; Forst, Jürgen // Archives of Orthopaedic & Trauma Surgery;Jun2010, Vol. 130 Issue 6, p775 

    Fractures are a common problem for patients with spinal muscular atrophy (SMA). A total of 131 patients with proximal SMA with an average age of 13.2 ± 9.2 years (0.7–65.6) were evaluated retrospectively. In 60 patients 94 different fractures were observed. The group consisted of 11...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics