TITLE

Identification and Replication of a Novel Obesity Locus on Chromosome 1q24 in Isolated Populations of Cilento

AUTHOR(S)
Ciullo, Marina; Nutile, Teresa; Dalmasso, Cyril; Sorice, Rossella; Bellenguez, Céline; Colonna, Vincenza; Persico, Maria Graziella; Bourgain, Catherine
PUB. DATE
March 2008
SOURCE
Diabetes;Mar2008, Vol. 57 Issue 3, p783
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE--Obesity is a complex trait with a variety of genetic susceptibility variants. Several loci linked to obesity and/or obesity-related traits have been identified, and relatively few regions have been replicated. Studying isolated populations can be a useful approach to identify rare variants that will not be detected with whole-genome association studies in large populations. RESEARCH DESIGN AND METHODS--Random individuals were sampled from Campora, an isolated village of the Cilento area in South Italy, phenotyped for BMI, and genotyped using a dense microsatellite marker map. An efficient pedigree-breaking strategy was applied to perform genome-wide linkage analyses of both BMI and obesity. Significance was assessed with ad hoc simulations for the two traits and with an original local false discovery rate approach to quantitative trait linkage analysis for BMI. A genealogy-corrected association test was performed for a single nucleotide polymorphism located in one of the linkage regions. A replication study was conducted in the neighboring village of Gioi. RESULTS--A new locus on chr1q24 significantly linked to BMI was identified in Campora. Linkage at the same locus is suggested with obesity. Three additional loci linked to BMI were also detected, including the locus including the INSIG2 gene region. No evidence of association between the rs7566605 variant and BMI or obesity was found. In Gioi, the linkage on chr1q24 was replicated with both BMI and obesity. CONCLUSIONS--Overall, our results confirm that successful linkage studies can be accomplished in these populations both to replicate known linkages and to identify novel quantitative trait linkages. Diabetes 57:783-790, 2008
ACCESSION #
31577908

 

Related Articles

  • NYD-SP18 is associated with obesity in the NHLBI Family Heart Study. Wilk, J. B.; Laramie, J. M.; Latourelle, J. C.; Williamson, S.; Nagle, M. W.; Tobin, J. E.; Foster, C. L.; Eckfeldt, J. H.; Province, M. A.; Borecki, I. B.; Myers, R. H. // International Journal of Obesity;Jun2008, Vol. 32 Issue 6, p930 

    Objective:The NHLBI Family Heart Study (FHS) genome-wide linkage scan identified a region of chromosome 7q with a logarithm of odds score of 4.9 for body mass index (BMI).Design:We report the results of fine mapping the linkage peak using 1020 single nucleotide polymorphisms (SNPs) to test for...

  • Association between a Common Variant near MC4R and Change in Body Mass Index Develops by Two Weeks of Age. Petry, Clive J.; López-Bermejo, Abel; Díaz, Marta; Sebastiani, Giorgia; Ong, Ken K.; de Zegher, Francis; Dunger, David B.; Ibáñez, Lourdes // Hormone Research in Paediatrics;Mar2010, Vol. 73 Issue 4, p275 

    Background/Aims: The common polymorphism rs17782313 lying 188 kb downstream of the MC4R gene has recently been found to be unequivocally associated with body mass index (BMI) and obesity risk in adults and children. Our objective was to test the association between rs17782313 and neonatal weight...

  • Multiple Genes Influence BMI on Chromosome 7q31–34: The NHLBI Family Heart Study. Laramie, Jason M.; Wilk, Jemma B.; Williamson, Sally L.; Nagle, Michael W.; Latourelle, Jeanne C.; Tobin, Jennifer E.; Province, Michael A.; Borecki, Ingrid B.; Myers, Richard H. // Obesity (19307381);Dec2009, Vol. 17 Issue 12, p2182 

    The National Heart, Lung, and Blood Institute Family Heart Study (FHS) genome-wide linkage scan identified a region of chromosome 7q31–34 with a lod score of 4.9 for BMI at D7S1804 (131.9 Mb). We report the results of linkage and association to BMI in this region for two independent FHS...

  • No association between LRP5 gene polymorphisms and bone and obesity phenotypes in Chinese male-offspring nuclear families. Jin-bo YU; Yao-hua KE; Jin-wei HE; Hao ZHANG; Wei-wei HU; Yun-qiu HU; Miao LI; Yu-juan LIU; Jie-mei GU; Wen-zhen FU; Gao GAO; Hua YUE; Wen-jin XIAO; Zhen-lin ZHANG // Acta Pharmacologica Sinica;Nov2010, Vol. 31 Issue 11, p1464 

    Aim:To investigate the effect of low-density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms on bone and obesity phenotypes in young Chinese men.Methods:A total of 1244 subjects from 411 Chinese nuclear families were genotyped by using the polymerase chain reaction-restriction...

  • Lack of Association of CD36 SNPs With Early Onset Obesity: A Meta-Analysis in 9,973 European Subjects. Choquet, Hélène; Labrune, Yann; De Graeve, Franck; Hinney, Anke; Hebebrand, Johannes; Scherag, André; Lecoeur, Cécile; Tauber, Maithé; Balkau, Beverley; Elliot, Paul; Jarvelin, Marjo-Riita; Walley, Andrew J.; Besnard, Philippe; Froguel, Philippe; Meyre, David // Obesity (19307381);Apr2011, Vol. 19 Issue 4, p833 

    A recent study suggested that four CD36 polymorphisms (namely rs3211867, rs3211883, rs3211908, and rs1527483) were associated with an increased risk of obesity, an increased BMI and percentage of body fat in European adolescents. We first attempted to confirm these results in three independent...

  • The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men. Armand Peeters; Sigri Beckers; Ilse Mertens; Wim Van Hul; Luc Van Gaal // Endocrine (1355008X);Apr2007, Vol. 31 Issue 2, p138 

    Since recent data suggest that the endocannabinoid system controls food intake through central, and lipogenesis via peripheral CB1 receptors, we hypothesized that genetic variation at the cannabinoid receptor-1 (CNR1) locus could have an effect on adiposity. We investigated, whether a specific...

  • Association of Two CETP Polymorphisms With HDL Levels in the Chinese Obese Population. Xiaoyang Ruan; Lina Ma; Shuyu Wang; Klaus Lindpaintner; Xiangjun Liu; Binbin Wang; Zuoqi Peng; Xu Ma; Maosheng Cheng; Jinghai Zhang; Lisheng Liu; Xingyu Wang // Obesity (19307381);Dec2009, Vol. 17 Issue 12, p2196 

    The association of two cholesterol ester transfer protein (CETP) polymorphisms, D442G and TAQIB (B1→B2), with high-density lipoprotein (HDL) levels in 932 Chinese obese individuals (BMI ≥ 27) was investigated in comparison with normal controls (BMI ≤ 24). Independent...

  • Replication and Extension of Association Between Common Genetic Variants in SIM1 and Human Adiposity. Swarbrick, Michael M.; Evans, Daniel S.; Valle, Maria. I.; Favre, Hélène; Wu, Shi-Hsuan; Njajou, Omer T.; Li, Rongling; Zmuda, Joseph M.; Miljkovic, Iva; Harris, Tamara B.; Kwok, Pui-Yan; Vaisse, Christian; Hsueh, Wen-Chi // Obesity (19307381);Dec2011, Vol. 19 Issue 12, p2394 

    Haplo-insufficiency of the bHLH (basic helix-loop-helix) transcription factor single-minded 1 (SIM1) causes severe obesity in mice and humans. We hypothesized that common genetic variations in/near SIM1 could exert more subtle effects on its function and associate with human adiposity. First,...

  • The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents. Hallman, D M; Friedel, V C; Eissa, M A H; Boerwinkle, E; Huber, J C; Harrist, R B; Srinivasan, S R; Chen, W; Dai, S; Labarthe, D R; Berenson, G S // International Journal of Obesity;Jan2012, Vol. 36 Issue 1, p61 

    OBJECTIVE:To investigate possible age-related changes in associations between polymorphisms in the fat mass and obesity-associated (FTO) gene and higher body mass index (BMI).DESIGN AND SUBJECTS:Multilevel mixed regression models were used to examine associations between four FTO variants and...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics