TITLE

Glucose-6-Phosphate Dehydrogenase Deficiency Enhances Human Coronavirus 229E Infection

AUTHOR(S)
Yi-Hsuan Wu; Ching-Ping Tseng; Mei-Ling Cheng; Hung-Yao Ho; Shin-Ru Shih; Daniel Tsun-Yee Chiu
PUB. DATE
March 2008
SOURCE
Journal of Infectious Diseases;3/15/2008, Vol. 197 Issue 6, p812
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The host cellular environment is a key determinant of pathogen infectivity. Viral gene expression and viral particle production of glucose-6-phosphate dehydrogenase (G6PD)-deficient and G6PD-knockdown cells were much higher than their counterparts when human coronavirus (HCoV) 229E was applied at 0.1 multiplicity of infection. These phenomena were correlated with increased oxidant production. Accordingly, ectopic expression of G6PD in G6PD-deficient cells or addition of antioxidant (such as α-lipoic acid) to G6PD-knockdown cells attenuated the increased susceptibility to HCoV229E infection. All experimental data indicated that oxidative stress in host cells is an important factor in HCoV229E infectivity.
ACCESSION #
31571109

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics