Inside inflammation: newly discovered receptors are key players in painful conditions

Kent, Heather
May 2000
CMAJ: Canadian Medical Association Journal;5/16/2000, Vol. 162 Issue 10, p1474
Academic Journal
Reports on a discovery by researchers from the University of Calgary of a mechanism that excites sensory nerves that play a role in inflammation. How proteases released from cells involved in the inflammatory process activate a class of receptors called proteinase activated receptors 2 (PAR2); Possibility that blocking PAR2 receptors may decrease inflammation; Ideas for a new drug based on PAR2 receptors; Discussion of the role of tryptase in the inflammatory process.


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