Exacerbations in cystic fibrosis: 4 Non-cystic fibrosis bronchiectasis

Chang, A. B.; Bilton, D.
March 2008
Thorax;Mar2008, Vol. 63 Issue 3, p269
Academic Journal
Bronchiectasis unrelated to cystic fibrosis (CF) is increasingly recognised as an important and major primary respiratory disease in developing countries. In affluent countries, bronchiectasis is also increasingly recognised in subsections of communities (such as indigenous peoples) as well as a co-existent disease/co-morbidity and disease modifier in respiratory diseases such as chronic obstructive pulmonary disease. The epidemiology, pathogenesis, prevention and management of exacerbations of non-CF bronchiectasis are reviewed. There are few data on all aspects of exacerbations in bronchiectasis. Some of the management issues are common to non-CF and CF bronchiectasis, but it would be unwise to extrapolate from CF studies to non-CF bronchiectasis. In some situations this may be harmful.


Related Articles

  • Diseases of the respiratory system. Hodson, Margaret E. // British Medical Journal;4/15/1978, Vol. 1 Issue 6118, p971 

    Focuses on bronchiectasis and cystic fibrosis, diseases of the respiratory system. Etiology; Symptoms and diagnosis; Causes; Treatment; Complications.

  • Pseudomonas aeruginosa Population Biology in Chronic Obstructive Pulmonary Disease. Rakhimova, Elza; Wiehlmann, Lutz; Brauer, Aimee L.; Sethi, Sanjay; Murphy, Timothy F.; Tümmler, Burkhard // Journal of Infectious Diseases;12/15/2009, Vol. 200 Issue 12, p1928 

    Background. The role played by airway infections with Pseudomonas aeruginosa in the course and pathogenesis of chronic obstructive pulmonary disease (COPD) has not yet been resolved. We report on the molecular epidemiology and population biology of P. aeruginosa in COPD. Methods. P. aeruginosa...

  • Sex differences in mouse models of asthma. Chang, Herng-Yu Sucie; Mitzner, Wayne // Canadian Journal of Physiology & Pharmacology;Dec2007, Vol. 85 Issue 12, p1226 

    Differences in disease susceptibility and prognosis between men and women are known to occur in the incidence and development of neurodegenerative, cardiovascular, and immunological disorders. In the lung there are also sex-based differences in the incidence, prevalence, and pathogenesis of lung...

  • The CLCA Gene Family: Putative Therapeutic Target for Respiratory Diseases. Winpenny, John P.; Marsey, Laura L.; Sexton, Darren W. // Inflammation & Allergy - Drug Targets;Jun2009, Vol. 8 Issue 2, p146 

    The CLCA proteins were first shown to exist in bovine trachea and named as chloride channels calcium activated (CLCA) due to the calcium-dependent chloride conductance that appeared to be activated on expression of these proteins in trachea and other secretory epithelial cells. Since their...

  • Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis. Oioo, J. C.; Mulrennan, S. A.; KasteIik, J. A.; Morice, A. H.; Redington, A. E. // Thorax;Jan2005, Vol. 60 Issue 1, p22 

    Background: It has been proposed that the ph of airway lining fluid may regulate the fractional exhaled concentration of nitric oxide (FENO) in respiratory disease. Methods: FENO, exhaled breath condensate (BC) ph, and BC concentrations of nitrite plus nitrate (NO2/NO3) were compared in 12...

  • What you don't know can hurt you; early asymptomatic lung disease in cystic fibrosis. Cunningham, Steve // Thorax;Oct2012, Vol. 67 Issue 10, p849 

    The author discusses the fate of early asymptomatic lung disease in cystic fibrosis (CF). He further discusses a study led by A.H. Hoo which provides evidence of early lung disease in patients with CF diagnosed by newborn screening. He suggests that surrogate biomarkers should be made primary...

  • Cough in Respiratory and Autoimmune Disorders. Fahim, A.; Hart, S. P.; Kastelik, J. A. // Current Respiratory Medicine Reviews;2011, Vol. 7 Issue 1, p21 

    Cough is one of the commonest symptoms of medical importance with significant physical and psychosocial morbidity associated with it. The differential diagnosis of cough is very extensive and it is extremely important to investigate this symptom in a systematic manner to accurately diagnose the...

  • Burden and trends of hospitalisations associated with pulmonary non-tuberculous mycobacterial infections in Germany, 2005-2011. Ringshausen, Felix C.; Apel, Rosa-Marie; Bange, Franz-Christoph; de Roux, Andrés; Pletz, Mathias W.; Rademacher, Jessica; Suhling, Hendrik; Wagner, Dirk; Welte, Tobias // BMC Infectious Diseases;2013, Vol. 13 Issue 1, p1 

    Background: Representative population-based data on the epidemiology of pulmonary non-tuberculous mycobacterial (PNTM) infections in Europe are limited. However, these data are needed in order to optimise patient care and to facilitate the allocation of healthcare resources. The aim of the...

  • THE CULTURE MICROBIOME IN THE LUNGS OF PATIENTS WITH COPD. Einarsson, G. G.; Comer, D.; Tunney, M. M.; Elborn, J. S. // Thorax;Dec2011 Supplement, pA48 

    Introduction and Aims Previous studies have shown that the lungs of Cystic Fibrosis (CF) and bronchiectasis (BE, not caused by CF) patients are colonised by a range of aerobic and anaerobic bacteria. As bacteria are also implicated in the pathogenesis and progression of chronic obstructive...


Read the Article


Sign out of this library

Other Topics