TITLE

Human Cytomegalovirus (HCMV) DNAemia in the Mother at Amniocentesis as a Risk Factor for Tatrogenic HCMV Infection of the Fetus

AUTHOR(S)
Revello, Maria Grazia; Furione, Milena; Zavattoni, Maurizio; Tassis, Beatrice; Nicolini, Umberto; Fabbri, Elisa; Gerna, Giuseppe
PUB. DATE
February 2008
SOURCE
Journal of Infectious Diseases;2/15/2008, Vol. 197 Issue 4, p593
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
To investigate whether invasive procedures performed in the presence of human cytomegalovirus (HCMV) DNA in maternal peripheral blood (HCMV DNAemia) represent a risk for iatrogenic transmission of HCMV infection to the fetus, 194 pregnant women undergoing prenatal diagnosis because of a primary HCMV infection and their 199 fetuses were investigated. Overall, 27 (37%) of 73 mothers of uninfected fetuses and 22 (37%) of 59 mothers of infected fetuses were HCMV DNAemia-positive at amniocentesis. Of the 8 mothers of the 8 fetuses with false-negative amniocentesis results, 4 were DNAemia-positive and 4 were DNAemia-negative at amniocentesis. Therefore, maternal HCMV DNAemia is not a significant risk factor for iatrogenic HCMV transmission to the fetus during amniocentesis.
ACCESSION #
31472916

 

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