Human Cytomegalovirus (HCMV) DNAemia in the Mother at Amniocentesis as a Risk Factor for Tatrogenic HCMV Infection of the Fetus

Revello, Maria Grazia; Furione, Milena; Zavattoni, Maurizio; Tassis, Beatrice; Nicolini, Umberto; Fabbri, Elisa; Gerna, Giuseppe
February 2008
Journal of Infectious Diseases;2/15/2008, Vol. 197 Issue 4, p593
Academic Journal
To investigate whether invasive procedures performed in the presence of human cytomegalovirus (HCMV) DNA in maternal peripheral blood (HCMV DNAemia) represent a risk for iatrogenic transmission of HCMV infection to the fetus, 194 pregnant women undergoing prenatal diagnosis because of a primary HCMV infection and their 199 fetuses were investigated. Overall, 27 (37%) of 73 mothers of uninfected fetuses and 22 (37%) of 59 mothers of infected fetuses were HCMV DNAemia-positive at amniocentesis. Of the 8 mothers of the 8 fetuses with false-negative amniocentesis results, 4 were DNAemia-positive and 4 were DNAemia-negative at amniocentesis. Therefore, maternal HCMV DNAemia is not a significant risk factor for iatrogenic HCMV transmission to the fetus during amniocentesis.


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