Potent Antimalarial and Transmission-Blocking Activities of Centanamycin, a Novel DNA-Binding Agent

Yanow, Stephanie K.; Purcell, Lisa A.; Pradel, Gabriele; Sato, Atsushi; Rodriguez, Ana; Lee, Moses; Spithill, Terry W.
February 2008
Journal of Infectious Diseases;2/15/2008, Vol. 197 Issue 4, p527
Academic Journal
Most treatments for malaria target the blood stage of infection in the human host, although few can also block transmission of the parasite to the mosquito. We show here that the compound centanamycin is very effective against blood-stage malarial infections in vitro and in vivo and has profound effects on sexual differentiation of the parasites in mosquitoes. After drug treatment, parasite development is arrested within the midguts of mosquitoes, failing to produce the infective forms that migrate to the salivary glands. The mechanism of parasite death is associated with modification of Plasmodium genomic DNA. We detected DNA damage in parasites isolated from mice 24 h after treatment with centanamycin, and, importantly, we also detected this DNA damage in parasites within mosquitoes that had fed on these mice 10 days earlier. This demonstrates that damage to parasite DNA during blood-stage infection persists from the vertebrate to the mosquito host and provides a novel biochemical strategy to block malaria transmission. -


Related Articles

  • Unrecognized Malaria and Its Consequences - A Case Report of Severe Malaria with Acute Renal Failure. Trošelj-Vukić, Biserka; Vuksanović-Mikuličić, Sretenka; Sladoje-Martinović, Branka; Milotić, Irena; Slavuljica, Irena // Collegium Antropologicum;Jun2013, Vol. 37 Issue 2, p611 

    Severe malaria is a medical emergency that requires urgent recognition and treatment, because it may rapidly prog-ress to serious complications and death. We report a case of imported severe malaria tropica in an adult traveller, with a parasitemia of 20%, complicated by acute renal failure....

  • Of Mosquitoes, Dead Birds and Epidemics. Jaroff, Leon; Barnes, Edward; Thompson, Dick // Time International (South Pacific Edition);10/11/99, Issue 41, p56 

    Mentions the 1999 epidemic of West Nile virus in metropolitan New York City. How the mosquito-borne disease was identified; Confusion with the St. Louis encephalitis virus.

  • When a pest turns menace.  // U.S. News & World Report;04/03/2000, Vol. 128 Issue 13, p48 

    Reports the outbreak of mosquito transmitted diseases from tropical places which are occurring in the United States. Discovery of West Nile fever in New York City in 1999; Outbreak of dengue fever in Texas in 1999, which was the worst in 20 years; Increases in transmission of tropical diseases...

  • Of Mosquitoes, Dead Birds and Epidemics. Jaroff, Leon; Barnes, Edward; Thompson, Dick // Time;10/11/1999, Vol. 154 Issue 15, p74 

    Mentions the 1999 epidemic of West Nile virus in metropolitan New York City. How the mosquito-borne disease was identified; Confusion with the St. Louis encephalitis virus.

  • Mosquitoes of Guam and the Northern Marianas: Distribution, Checklists, and Notes on Mosquito-Borne Pathogens. Rueda, Leopoldo M.; Nunn, Peter V.; Pecor, James E.; Rabago, Rosanna Y.; Reeves, Will K.; Gutierrez, Teresa L.; Wolf, Stephen P.; Debboun, Mustapha // U.S. Army Medical Department Journal;Jul/Sep2011, p17 

    This report includes the distribution records and updated checklists of the mosquitoes known to occur in Guam and nearby selected islands (ie, Saipan, Tinian, Rota), based on our field collections from various localities during 2010, published reports, and accessioned specimens deposited in the...

  • LABORATORY STUDIES ON THE TRANSMISSION OF YELLOW FEVER VIRUS BY AEDES (FINLAYA) NOTOSCRIPTUS (DIPT., CULICIDAE). Russell, R.C.; Mukwaya, L.G.; Lule, M. // Australian Journal of Experimental Biology & Medical Science;Dec1977, Vol. 55 Issue 6, p649 

    Highlights the results of laboratory studies on the transmission of yellow fever virus by aedes (Finlaya) notoscriptus (skuse), a mosquito which occupies a similar ecological niche to aedes (Stegomyia) aegypti (L). Possibility of local urban mosquito vectors for the virus and their distribution;...

  • RE-EMERGENCE OF ANOPHELES FUNESTUS AND ITS POSSIBLE EFFECT ON MALARIA TRANSMISSION ON MAYOTTE ISLAND, INDIAN OCEAN. Elissa, N.; Karch, S. // Journal of the American Mosquito Control Association;2005, Vol. 21 Issue 4, p472 

    Malaria constitutes a major public health problem on Mayotte Island, with the major vector being Anopheles gambiae s.s. The seeming disappearance of An. funestus, the 2nd vector on the island, was observed 15 years ago. Now, the presence of An. funestus during the biting collections performed in...

  • On the Delayed Ross-Macdonald Model for Malaria Transmission. Ruan, Shigui; Xiao, Dongmei; Beier, John C. // Bulletin of Mathematical Biology;May2008, Vol. 70 Issue 4, p1098 

    The feedback dynamics from mosquito to human and back to mosquito involve considerable time delays due to the incubation periods of the parasites. In this paper, taking explicit account of the incubation periods of parasites within the human and the mosquito, we first propose a delayed...

  • Mosquito-Borne West Nile Turns Up in an Unsuspected Carrier: the American Robin. Netting, Jessa Forte // Discover;Jan2006, Vol. 27 Issue 1, p49 

    The article states that medical entomologists at the Connecticut Agricultural Experiment Station have discovered that 40 percent of mosquitoes infected by the West Nile virus had feasted on the blood of the American robin, a bird species that can carry the virus without showing symptoms. So far...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics