TITLE

Genome-wide differences in hepatitis C- vs alcoholism-associated hepatocellular carcinoma

AUTHOR(S)
Derambure, Céline; Coulouarn, Cédric; Caillot, Frédérique; Daveau, Romain; Hiron, Martine; Scotte, Michel; François, Arnaud; Duclos, Celia; Goria, Odile; Gueudin, Marie; Cavard, Catherine; Terris, Benoit; Daveau, Maryvonne; Salier, Jean-Philippe; Rippe, Richard A.
PUB. DATE
March 2008
SOURCE
World Journal of Gastroenterology;3/21/2008, Vol. 14 Issue 11, p1749
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
AIM: To look at a comprehensive picture of etiology-dependent gene abnormalities in hepatocellular carcinoma in Western Europe. METHODS: With a liver-oriented microarray, transcript levels were compared in nodules and cirrhosis from a training set of patients with hepatocellular carcinoma (alcoholism, 12; hepatitis C, 10) and 5 controls. Loose or tight selection of informative transcripts with an abnormal abundance was statistically valid and the tightly selected transcripts were next quantified by qRTPCR in the nodules from our training set (12 + 10) and a test set (6 + 7). RESULTS: A selection of 475 transcripts pointed to significant gene over-representation on chromosome 8 (alcoholism) or -2 (hepatitis C) and ontology indicated a predominant inflammatory response (alcoholism) or changes in cell cycle regulation, transcription factors and interferon responsiveness (hepatitis C). A stringent selection of 23 transcripts whose differences between etiologies were significant in nodules but not in cirrhotic tissue indicated that the above dysregulations take place in tumor but not in the surrounding cirrhosis. These 23 transcripts separated our test set according to etiologies. The inflammation-associated transcripts pointed to limited alterations of free iron metabolism in alcoholic vs hepatitis C tumors. CONCLUSION: Etiology-specific abnormalities (chromosome preference; differences in transcriptomes and related functions) have been identified in hepatocellular carcinoma driven by alcoholism or hepatitis C. This may open novel avenues for differential therapies in this disease.
ACCESSION #
31436365

 

Related Articles

  • Integrated Analysis of Whole Genome and Transcriptome Sequencing Reveals Diverse Transcriptomic Aberrations Driven by Somatic Genomic Changes in Liver Cancers. Shiraishi, Yuichi; Fujimoto, Akihiro; Furuta, Mayuko; Tanaka, Hiroko; Chiba, Ken-ichi; Boroevich, Keith A.; Abe, Tetsuo; Kawakami, Yoshiiku; Ueno, Masaki; Gotoh, Kunihito; Ariizumi, Shun-ichi; Shibuya, Tetsuo; Nakano, Kaoru; Sasaki, Aya; Maejima, Kazuhiro; Kitada, Rina; Hayami, Shinya; Shigekawa, Yoshinobu; Marubashi, Shigeru; Yamada, Terumasa // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1 

    Recent studies applying high-throughput sequencing technologies have identified several recurrently mutated genes and pathways in multiple cancer genomes. However, transcriptional consequences from these genomic alterations in cancer genome remain unclear. In this study, we performed integrated...

  • Network analysis of microRNAs, genes and their regulation in human bladder cancer. YANG LI; ZHIWEN XU; KUNHAO WANG; NING WANG; MINGHUI ZHU // Biomedical Reports;2013, Vol. 1 Issue 6, p918 

    Bladder cancer (BC) is the fifth most common malignancy occurring worldwide and a significant cause of cancer-related morbidity and mortality. Although BC is a serious health issue, studies available concerning the relationship of genes, microRNAs (miRNAs) and their host genes has been lacking....

  • Characterizing the cancer genome in lung adenocarcinoma. Weir, Barbara A.; Woo, Michele S.; Getz, Gad; Perner, Sven; Li Ding; Beroukhim, Rameen; Lin, William M.; Province, Michael A.; Kraja, Aldi; Johnson, Laura A.; Shah, Kinjal; Sato, Mitsuo; Thomas, Roman K.; Barletta, Justine A.; Borecki, Ingrid B.; Broderick, Stephen; Chang, Andrew C.; Chiang, Derek Y.; Chirieac, Lucian R.; Jeonghee Cho // Nature;12/6/2007, Vol. 450 Issue 7171, p893 

    Somatic alterations in cellular DNA underlie almost all human cancers. The prospect of targeted therapies and the development of high-resolution, genome-wide approaches are now spurring systematic efforts to characterize cancer genomes. Here we report a large-scale project to characterize...

  • Characterization of a Human Cell Line Stably Over-Expressing the Candidate Oncogene, Dual Specificity Phosphatase 12. Cain, Erica L.; Braun, Sterling E.; Beeser, Alexander // PLoS ONE;2011, Vol. 6 Issue 4, p1 

    Background: Analysis of chromosomal rearrangements within primary tumors has been influential in the identification of novel oncogenes. Identification of the ''driver'' gene(s) within cancer-derived amplicons is, however, hampered by the fact that most amplicons contain many gene products....

  • The Fission Yeast Homeodomain Protein Yox1p Binds to MBF and Confines MBF-Dependent Cell-Cycle Transcription to G1-S via Negative Feedback. Aligianni, Sofia; Lackner, Daniel H.; Klier, Steffi; Rustici, Gabriella; Wilhelm, Brian T.; Marguerat, Samuel; Codlin, Sandra; Brazma, Alvis; de Bruin, Robertus A. M.; Bähler, Jürg // PLoS Genetics;Aug2009, Vol. 5 Issue 8, p1 

    The regulation of the G1- to S-phase transition is critical for cell-cycle progression. This transition is driven by a transient transcriptional wave regulated by transcription factor complexes termed MBF/SBF in yeast and E2F-DP in mammals. Here we apply genomic, genetic, and biochemical...

  • Cyclin A1 is a transcriptional target of PITX2 and overexpressed in papillary thyroid carcinoma. Liu, Yan; Huang, Yue; Zhu, Guo-Zhang // Molecular & Cellular Biochemistry;Dec2013, Vol. 384 Issue 1/2, p221 

    Physiological expression of cyclin A1, a unique cell cycle regulator essential for spermatogenesis, is predominantly restricted in male germ cells. Outstandingly, previous studies have also demonstrated the abnormal expression of cyclin A1 in various human tumors. How male germ cell-specific...

  • hSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomas. Xu, S; Feng, Z; Zhang, M; Wu, Y; Sang, Y; Xu, H; Lv, X; Hu, K; Cao, J; Zhang, R; Chen, L; Liu, M; Yun, J-P; Zeng, Y-X; Kang, T // Oncogene;5/12/2011, Vol. 30 Issue 19, p2219 

    Downregulation of hSSB1, a single-stranded DNA-binding protein, causes increased radiosensitivity, defective checkpoint activation and genomic instability. However, the mechanisms of hSSB1 function in these responses remain to be uncovered. Here, we present evidence that hSSB1 directly binds p21...

  • Recurrent Targeted Genes of Hepatitis B Virus in the Liver Cancer Genomes Identified by a Next-Generation Sequencing--Based Approach. Dong Ding; Xiaoyan Lou; Dasong Hua; Wei Yu; Lisha Li; Jun Wang; Feng Gao; Na Zhao; Guoping Ren; Lanjuan Li; Biaoyang Lin // PLoS Genetics;Dec2012, Vol. 8 Issue 12, p1 

    Integration of the viral DNA into host chromosomes was found in most of the hepatitis B virus (HBV)--related hepatocellular carcinomas (HCCs). Here we devised a massive anchored parallel sequencing (MAPS) method using next-generation sequencing to isolate and sequence HBV integrants. Applying...

  • Targeting proliferating tumor cells via the transcriptional control of therapeutic genes. Ho, I. A. W.; Hui, K. M.; Lam, P. Y. P. // Cancer Gene Therapy;Jan2006, Vol. 13 Issue 1, p44 

    We have previously reported the construction of a cell cycle-regulated HSV-1 amplicon vector (denoted as pC8-36) that confers luciferase reporter gene activities dependent on cellular divisions. However, luciferase reporter gene is well known for its relatively high sensitivity, thus, it is...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics