TITLE

Tumor suppressor and hepatocellular carcinoma

AUTHOR(S)
Martin, Juliette; Dufour, Jean-François; Fukui, Hirokazu
PUB. DATE
March 2008
SOURCE
World Journal of Gastroenterology;3/21/2008, Vol. 14 Issue 11, p1720
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A few signaling pathways are driving the growth of hepatocellular carcinoma. Each of these pathways possesses negative regulators. These enzymes, which normally suppress unchecked cell proliferation, are circumvented in the oncogenic process, either the over-activity of oncogenes is sufficient to annihilate the activity of tumor suppressors or tumor suppressors have been rendered ineffective. The loss of several key tumor suppressors has been described in hepatocellular carcinoma. Here, we systematically review the evidence implicating tumor suppressors in the development of hepatocellular carcinoma.
ACCESSION #
31436362

 

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