TITLE

Hepatocellular carcinoma, human immunodeficiency virus and viral hepatitis in the HAART era

AUTHOR(S)
Macdonald, Douglas C.; Nelson, Mark; Bower, Mark; Powles, Thomas; Rosa, Heitor
PUB. DATE
March 2008
SOURCE
World Journal of Gastroenterology;3/21/2008, Vol. 14 Issue 11, p1657
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The incidence of hepatocellular carcinoma (HCC) in patients with human immunodeficiency virus (HIV) is rising. HCC in HIV almost invariably occurs in the context of hepatitis C virus (HCV) or hepatitis B virus (HBV) co-infection and, on account of shared modes of transmission, this occurs in more than 33% and 10% of patients with HIV worldwide respectively. It has yet to be clearly established whether HIV directly accelerates HCC pathogenesis or whether the rising incidence is an epiphenomenon of the highly active antiretroviral therapy (HAART) era, wherein the increased longevity of patients with HIV allows long-term complications of viral hepatitis and cirrhosis to develop. Answering this question will have implications for HCC surveillance and the timing of HCV/HBV therapy, which in HIV co-infection presents unique challenges. Once HCC develops, there is growing evidence that HIV co-infection should not preclude conventional therapeutic strategies, including liver transplantation.
ACCESSION #
31436355

 

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