Natural history of hepatitis-related hepatocellular carcinoma

Yiu-Kuen But, David; Ching-Lung Lai; Man-Fung Yuen; Carneiro De Moura, Miguel
March 2008
World Journal of Gastroenterology;3/21/2008, Vol. 14 Issue 11, p1652
Academic Journal
Hepatocellular carcinoma (HCC) is an important cause of cancer death in the world. It has great regional differences in the pathology and epidemiology. The variation is greatly influenced by the aetiologies of the disease. Hepatitis B and C infection are the most important risk factors. HCC incidence rates are higher but in decreasing trend in developing countries. However, the figures in the developed countries are contrary. Successful hepatitis B virus (HBV) vaccination programs, better food hygiene, increased global hepatitis C virus (HCV) prevalence and population migration are the possible explanations. A number of clinical and pathogenic differences exist between HBV- and HCV-related HCC. HBV infection leads to the development of HCC through direct and indirect pathways as it has the ability to integrate into the host genome affecting cellular signaling and growth control. HCV causes HCC mainly through indirect pathways: chronic inflammation, cell deaths and proliferation. As a result, HCC is almost exclusively found in cirrhotic HCV patients while HCC is sometimes found in HBV patients without significant liver cirrhosis. Due to the different severities of liver cirrhosis and HCC extent, therapeutic strategies from resection, liver transplantation to symptoms palliation are available. Poorly differentiated histology, lack of fibrous capsule, large tumour size, early vascular invasion and elevated serum levels of alpha fetoprotein (AFP) are the features for more aggressive disease. Combined with markers of liver reserve and performance status, accurate scoring systems and models have been developed to predict patients' survival and match best treatment option.


Related Articles

  • Plasma Selenium Levels and Risk of Hepatocellular Carcinoma among Men with Chronic Hepatitis Virus Infection. Yu, Ming-Whei; Horng, Ing-Sheng; Hsu, Kuang-Hung; Chiang, Yi-Ching; Liaw, Yun Fan; Chen, Chien-Jen // American Journal of Epidemiology;1999, Vol. 150 Issue 4, p367 

    Both experimental and epidemiologic studies have linked a low dietary intake of selenium with an increased risk of cancer. The authors examined the association between plasma selenium levels and risk of hepatocellular carcionoma (HCC) among chronic carriers of hepatitis B and/or C virus in a...

  • Associations Between Hepatitis B Virus Genotype and Mutants and the Risk of Hepatocellular Carcinoma. Hwai-I Yang; Shiou-Hwei Yeh; Pei-Jer Chen; Iloeje, Uchenna H.; Chin-Lan Jen; Jun Su; Li-Yu Wang; Sheng-Nan Lu; San-Lin You; Ding-Shinn Chen; Yun-Fan Liaw; Chien-Jen Chen // JNCI: Journal of the National Cancer Institute;8/20/2008, Vol. 100 Issue 16, p1134 

    Background The risk of hepatocellular carcinoma (HCC) increases with increasing level of hepatitis B virus (HBV) in serum (viral load). However, it is unclear whether genetic characteristics of HBV, including HBV genotype and specific genetic mutations, contribute to the risk of HCC. We examined...

  • The effect of interaction between hepatitis C virus and cigarette smoking on the risk of hepatocellular carcinoma. Fujita, Y.; Shibata, A.; Ogimoto, I.; Kurozawa, Y.; Nose, T.; Yoshimura, T.; Suzuki, H.; Iwai, N.; Sakata, R.; Ichikawa, S.; Tamakoshi, A. // British Journal of Cancer;3/13/2006, Vol. 94 Issue 5, p737 

    We evaluated the interaction between hepatitis C virus (HCV) and cigarette smoking on death from hepatocellular cancer in The Japan Collaborative Cohort Study. The odds ratio of death from HCC for smoking was 9.60 (1.50–61.35) and 1.71(0.58–5.08) among anti-HCV positive and...

  • Multi-TGDR, a multi-class regularization method, identifies the metabolic profiles of hepatocellular carcinoma and cirrhosis infected with hepatitis B or hepatitis C virus. Suyan Tian; Chang, Howard H.; Chi Wang; Jing Jiang; Xiaomei Wang; Junqi Niu // BMC Bioinformatics;2014, Vol. 15 Issue 1, p1 

    Background Over the last decade, metabolomics has evolved into a mainstream enterprise utilized by many laboratories globally. Like other "omics" data, metabolomics data has the characteristics of a smaller sample size compared to the number of features evaluated. Thus the selection of an...

  • Hepatitis C virus linked to liver cancer.  // Cancer News;Autumn90, Vol. 44 Issue 3, p16 

    Focuses on the study sponsored by the American Cancer Society (ACS) which shows a strong association between hepatitis C virus (HCV) and liver cancer. Statement of Mimi C. Yu, principal investigator of the study about individuals who tested positive for the HCV virus; Percentage of liver cancer...

  • Smoking, Hepatitis B Virus Infection, and Development of Hepatocellular Carcinoma. Sherman, Morris; Llovet, Josep M. // JNCI: Journal of the National Cancer Institute;Nov2011, Vol. 103 Issue 22, p1642 

    An introduction to the journal is presented in which the editor discusses two articles published within the issue on the risk factors for hepatocellular carcinoma including one on the incidence of hepatocellular carcinoma in Greenlanders with chronic Hepatitis B virus (HBV) infection, and...

  • Hepatocellular carcinoma and chronic HCV infection.  // American Family Physician;2/15/1996, Vol. 53 Issue 3, p947 

    Presents the study `Randomized Trial of Effects of Interferon-alpha on Incidence of Hepatocellular Carcinoma in Chronic Active Hepatitis C With Cirrhosis,' by Nishiguchi, S., et al, published in the 1995 issue the periodical `Lancet.' Clinical trial; Effectiveness of interferon-alpha therapy in...

  • Hepatitis C virus infection and risk of hepatocellular carcinoma among Japanese: Possible role of... Tanaka, Keitaro; Ikematsu, Hideyuki // JNCI: Journal of the National Cancer Institute;06/5/96, Vol. 88 Issue 11, p742 

    Presents a case-control study to estimate the relative risk (RR) of hepatocellular carcinoma (HCC) in relation to hepatitis C virus (HCV) infection among residents of Fukuoka Prefecture, Japan. Elevated risk of HCC related to HCV infection; Susceptibility of individuals with type 1B HCV...

  • Ultrasonography in the study of hepatocellular carcinoma in woodchucks chronically infected with WHV. D. Lisi; L. A. Kondili; M. T. Ramieri; R. Giuseppetti; R. Bruni; C. Della Rocca; A. De Santis; M. Rapicetta // Laboratory Animals;Jul2003, Vol. 37 Issue 3, p233 

    The woodchuck hepatitis virus (WHV)/woodchuck system is studied as animal model of human hepatocellular carcinoma (HCC) induced by chronic hepatitis B virus infection. The aim of the present study was the evaluation of ultrasound (US) liver examination in woodchuck as a routine method to detect...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics