TITLE

A CHANGED VIEW OF SERUM PREALBUMIN IN THE ELDERLY: PREALBUMIN VALUES INFLUENCED BY CONCOMITANT INFLAMMATION

AUTHOR(S)
Hrnciarikova, Dana; Juraskova, Bozena; Hyspler, Radomir; Solichova, Dagmar; Ticha, Alena; Klemera, Petr; Hronek, Miloslav; Zadak, Zdenek
PUB. DATE
December 2007
SOURCE
Biomedical Papers of the Medical Faculty of Palacky University i;2007, Vol. 151 Issue 2, p273
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aims: We are currently witnessing changes in views on the evaluation of serum proteins. A decrease may signal not only malnutrition. It may also be an indicator of simultaneously occurring inflammatory disease. Prealbumin, due to its short half-life, is a suitable indicator of changes in protein-energy balance, but its levels show, as with other serum proteins, a decrease in the case of inflammation too. The present study aimed to determine the prealbumin values of hospitalized geriatric patients and how they are affected by inflammatory disease. Methods: In 101 patients aged over 80 years, the relationships were compared between prealbumin and C-reactive protein in the whole group and then in the subgroups with normal and increased C-reactive protein. Results: In 67.33 % of hospitalized geriatric patients prealbumin was below the limit of the norm. A statistically highly signifi cant dependence (p < 0.001) was demonstrated between a decrease in prealbumin and an increase in Creactive protein in the whole group. In the subgroup with normal C-reactive protein, no statistically signifi cant decrease in prealbumin was demonstrated, whereas in the subgroup with increased C-reactive protein a signifi cant decrease in prealbumin (p < 0.001 for the whole group, p < 0.01 men, p < 0.05 women) was found. Conclusions: The study demonstrated subnormal mean initial values of prealbumin and a highly statistically significant negative correlation between a decrease in prealbumin and an increase in C-reactive protein in the whole group. We confirm that in inflammation there is a statistically significant decrease in serum concentration of prealbumin.
ACCESSION #
31371838

 

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